ArticleCongestive heart failure (Greenwich, Conn.)
Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure.
Article in Congestive heart failure (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Reprogramming heart failure: physiological orchestration and mechanistic decoding of exercise benefits.BMC cardiovascular disorders · 2025Pooled it
- Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies.Neurology · 2025Pooled it
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Atrial fibrillation and cognitive function in patients with heart failure: a systematic review and meta-analysis.Heart failure reviews · 2017Pooled it
- Cerebral blood flow in small vessel disease: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Pooled it
- Nutrition and Cognition in Older Adults With Heart Failure: A Systematic Review.Journal of gerontological nursing · 2015Pooled it
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
- Cerebral Hypoperfusion Causes Behavioral Changes and Impairs the Rod Photoreceptor Pathway in the Retina of Aged Mice.Cellular and molecular neurobiology · 2026Article
- Dynamical Regulation of Blood Pressure and Cognitive Function.American journal of hypertension · 2026Article
- Deep cervical lymphatic-venous anastomosis in dementia: a clinical and mechanistic evaluation.International journal of surgery (London, England) · 2025Article
- The heart-brain axis: neurocognitive frailty in heart failure.Journal of neurology · 2025Review
- Uncovering Proteins Commonly Expressed Between Heart Failure and Dementia Using Bioinformatic Tools.Current issues in molecular biology · 2025Article
- The Heart-Brain Axis: Key Concepts in Neurocardiology.Cardiology discovery · 2025Review
- Left Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke and Dementia Risk: The Multi-Ethnic Study of Atherosclerosis.Neurology · 2025Observational
- Outcomes of Mechanical Thrombectomy in Patients With Ischemic Stroke and Heart Failure. A Systematic Review and Meta-analysis.Stroke (Hoboken, N.J.) · 2025Article
- Prediction models for cognitive impairment in middle-aged patients with cerebral small vessel disease.Frontiers in neurology · 2025Article
- Neuroimaging Links Between Heart Failure and Depression-A Narrative Review.Brain sciences · 2024Review
- Cognitive impairment in heart failure patients: association with abnormal circadian blood pressure rhythm: a review from the HOPE Asia Network.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- The impact of body position on neurofluid dynamics: present insights and advancements in imaging.Frontiers in aging neuroscience · 2024Review
- Mechanisms of mitophagy and oxidative stress in cerebral ischemia-reperfusion, vascular dementia, and Alzheimer's disease.Frontiers in molecular neuroscience · 2024Review
11 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
Abstract
Cognitive impairment is common in heart failure (HF) and believed to be the result of cerebral hypoperfusion and subsequent brain changes including white matter hyperintensities (WMHs). The current study examined the association between cerebral blood flow and WMHs in patients with HF and the relationship between WMHs and cognitive impairment. Sixty-nine patients with HF completed the Mini-Mental State Examination (MMSE) and underwent echocardiography, transcranial Doppler sonography for cerebral blood flow velocity of the middle cerebral artery, and brain magnetic resonance imaging. Multivariable hierarchical regression analyses controlling for medical and demographic characteristics as well as intracranial volume showed reduced cerebral blood flow velocity of the middle cerebral artery was associated with greater WMHs (β=-0.34, P=.02). Follow-up regression analyses adjusting for the same medical and demographic factors in addition to cerebral perfusion also revealed marginal significance between increased WMHs and poorer performance on the MMSE (β=-0.26, P=.05). This study suggests that reduced cerebral perfusion is associated with greater WMHs in older adults with HF. These findings support the widely proposed mechanism of cognitive impairment in HF patients and prospective studies are needed to confirm these results.
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