Evidence map›Paper›PMID 23517118›Full record

Trial reportThe New England journal of medicine2013

A behavioral weight-loss intervention in persons with serious mental illness.

Gail L Daumit, Faith B Dickerson, Nae-Yuh Wang, Arlene Dalcin, Gerald J Jerome, Cheryl A M Anderson, Deborah R Young, Kevin D Frick, Airong Yu, Joseph V Gennusa and 8 more

4 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The New England journal of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 246 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 17 pooled it
32.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00902694 nacompletednot on this map

Randomized Trial Of Achieving Healthy Lifestyles In Psychiatric Rehabilitation

TypeinterventionalSponsorJohns Hopkins UniversityRan2008 to 2012Enrolled291ConditionsOverweight and ObesityArmsACHIEVE Intervention, Control
NCT02451670 nacompletednot on this mapstarted 2016, after this paper: background citation

Reducing Cardiovascular Risk in Adults With Serious Mental Illness Using an Electronic Medical Record-based Clinical Decision Support

TypeinterventionalSponsorHealthPartners InstituteRan2016 to 2018Enrolled10,347ConditionsChronic Disease, Mental Disorder, Health Behavior, Bipolar DisorderArmsPrioritized Clinical Decision Support
NCT03695289 nacompletednot on this mapstarted 2018, after this paper: background citation

Adaptation of an Evidence-based Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness

TypeinterventionalSponsorWashington University School of MedicineRan2018 to 2020Enrolled30ConditionsObesity, Mentally Ill PersonsArmsiOTA SMI, Health Education Control
NCT03999892 nacompletednot on this mapstarted 2019, after this paper: background citation

ACHIEVE-D Pilot Study

TypeinterventionalSponsorJohns Hopkins UniversityRan2019 to 2019Enrolled17ConditionsObesity, Mental Disorders, SevereArmsACHIEVE
3 · Its place in the literature

Who cites it

246 citing papers in PubMed, 17 syntheses or guidelines pooled it, 521 citations in OpenAlex.

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  15. Dietary advice for people with schizophrenia.The Cochrane database of systematic reviews · 2016
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  17. Patient outcomes following discharge from secure psychiatric hospitals: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science · 2016
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186 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Gail L DaumitWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA. gdaumit@jhmi.edu
Faith B Dickerson
Nae-Yuh Wang
Arlene Dalcin
Gerald J Jerome
Cheryl A M Anderson
Deborah R Young
Kevin D Frick
Airong Yu
Joseph V Gennusa
Meghan Oefinger
Rosa M Crum
Jeanne Charleston
Sarah S Casagrande
Eliseo Guallar
Richard W Goldberg
Leslie M Campbell
Lawrence J Appel
Johns Hopkins University · USSheppard and Enoch Pratt Hospital · USSocial and Scientific Systems (United States) · USUniversity of California San Diego · USUniversity of Maryland, Baltimore · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Diabetes Research and Training CenterP60DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2008 to 2012
$9.1M
Randomized Trial of Achieving Healthy Lifestyles in Psych RehabilitationR01MH080964 · NIMH · JOHNS HOPKINS UNIVERSITY · PI DAUMIT, GAIL L. · 2008 to 2012
$5.2M
IMPLEMENTATION RESEARCH INSTITUTE FOR MENTAL HEALTH SERVICES IRI-MHSR25MH080916 · NIMH · WASHINGTON UNIVERSITY · PI Byron James Powell · 2009 to 2026
$3.7M
NCRR NIH HHS UL1 RR025005NIDDK NIH HHS P30 DK079637NIDDK NIH HHS P60 DK079637NIMH NIH HHS R01 MH080964NIMH NIH HHS R25 MH080916
6 · The paper itself

Abstract

backgroundOverweight and obesity are epidemic among persons with serious mental illness, yet weight-loss trials systematically exclude this vulnerable population. Lifestyle interventions require adaptation in this group because psychiatric symptoms and cognitive impairment are highly prevalent. Our objective was to determine the effectiveness of an 18-month tailored behavioral weight-loss intervention in adults with serious mental illness.

methodsWe recruited overweight or obese adults from 10 community psychiatric rehabilitation outpatient programs and randomly assigned them to an intervention or a control group. Participants in the intervention group received tailored group and individual weight-management sessions and group exercise sessions. Weight change was assessed at 6, 12, and 18 months.

resultsOf 291 participants who underwent randomization, 58.1% had schizophrenia or a schizoaffective disorder, 22.0% had bipolar disorder, and 12.0% had major depression. At baseline, the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 36.3, and the mean weight was 102.7 kg (225.9 lb). Data on weight at 18 months were obtained from 279 participants. Weight loss in the intervention group increased progressively over the 18-month study period and differed significantly from the control group at each follow-up visit. At 18 months, the mean between-group difference in weight (change in intervention group minus change in control group) was -3.2 kg (-7.0 lb, P=0.002); 37.8% of the participants in the intervention group lost 5% or more of their initial weight, as compared with 22.7% of those in the control group (P=0.009). There were no significant between-group differences in adverse events.

conclusionsA behavioral weight-loss intervention significantly reduced weight over a period of 18 months in overweight and obese adults with serious mental illness. Given the epidemic of obesity and weight-related disease among persons with serious mental illness, our findings support implementation of targeted behavioral weight-loss interventions in this high-risk population. (Funded by the National Institute of Mental Health; ACHIEVE ClinicalTrials.gov number, NCT00902694.).

Indexed as

Behavior TherapyWeight LossAdultBody Mass IndexFemaleHumansMaleMental DisordersMiddle AgedObesityOverweightPatient Compliance

Identifiers

PMID23517118
PMCPMC3743095
OpenAlexW2147474481

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.