Evidence map›Paper›PMID 23516986›Full record

ReviewAnnual review of immunology2013

T cell-mediated host immune defenses in the lung.

Kong Chen, Jay K Kolls

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 230 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025
    Review
  8. Review
  9. Review
  10. Immunobiology of pulmonary fibrosis.Frontiers in immunology · 2025
    Review
  11. Host Immune Response toJournal of inflammation research · 2025
    Review
  12. Microorganisms · 2024
    Article
  13. The standardization and efficacy of fermentedOpen veterinary journal · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Journal of clinical tuberculosis and other mycobacterial diseases · 2024
    Review
  18. Development and validation of an online dynamic nomogram system for pulmonary consolidation in children with Mycoplasma pneumoniae pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  19. Article
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kong ChenRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15201, USA.
Jay K Kolls
Children's Hospital of Pittsburgh · USRichard King Mellon Foundation · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Surrogate Biomarkers for Disease Progression in IPFP50HL084932 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, ANURADHA · 2006 to 2010
$12.2M
T-Cells and P. Carinii PneumoniaR01HL062052 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 1998 to 2017
$5.1M
Th17 Cytokines and Lung ImmunityR37HL079142 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2010 to 2017
$3.6M
NON CD4 HOST DEFENSE AGAINST P CARINII PNEUMONIAR01HL061271 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 1999 to 2013
$3.6M
Alcohol, ROS, and Macrophage EpigeneticsR01AA016688 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2006 to 2010
$1.8M
NCATS NIH HHS UL1 TR000005NHLBI NIH HHS 5R01HL061271NHLBI NIH HHS P50 HL084932NHLBI NIH HHS P50HL084932NHLBI NIH HHS R01 HL061271NHLBI NIH HHS R01 HL062052NHLBI NIH HHS R37 HL079142NHLBI NIH HHS R37-HL079142NIAAA NIH HHS R01 AA016688
6 · The paper itself

Abstract

Evidence has increasingly shown that the lungs are a major site of immune regulation. A robust and highly regulated immune response in the lung protects the host from pathogen infection, whereas an inefficient or deleterious response can lead to various pulmonary diseases. Many cell types, such as epithelial cells, dendritic cells, macrophages, neutrophils, eosinophils, and B and T lymphocytes, contribute to lung immunity. This review focuses on the recent advances in understanding how T lymphocytes mediate pulmonary host defenses against bacterial, viral, and fungal pathogens.

Indexed as

AnimalsCD4-Positive T-LymphocytesHost-Pathogen InteractionsHumansLungLymph NodesMycobacterium tuberculosisTuberculosis, Pulmonary

Identifiers

PMID23516986
PMCPMC3912562
OpenAlexW2170374271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.