ArticlePLoS genetics2013
Complex patterns of genomic admixture within southern Africa.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Craniometric evaluation of population affinity among South African subadults.International journal of legal medicine · 2026Article
- Recovering the precolonial population structure of Khoe-San descendant populations.Science advances · 2026Article
- Three methods of estimating age-at-death using three different regions on the os coxa.Journal of forensic sciences · 2026Article
- A catalogue of early diverged contemporary human genome variation reveals distinct Khoe-San populations.Nature communications · 2026Article
- Characterization of the oral microbiome in the diverse South African population by PacBio HiFi sequencing.Applied microbiology and biotechnology · 2026Article
- Responding to the call: Population affinity estimation in a South African forensic context of identification - are we helping or harming?Forensic science international. Synergy · 2025Article
- Recovering the pre-colonial population structure of Khoe-San descendant populations.bioRxiv : the preprint server for biology · 2025Article
- The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa.American journal of human genetics · 2025Article
- Population affinity estimation in forensic anthropology: a South African perspective.International journal of legal medicine · 2025Review
- From individuals to ancestries: Towards attributing trait variation to haplotypes.PLoS genetics · 2025Article
- Wide-scale geographical analysis of genetic ancestry in the South African Coloured population.BMC biology · 2025Article
- Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations.Annals of human genetics · 2025Article
- Evaluating variant pathogenicity prediction tools to establish African inclusive guidelines for germline genetic testing.Communications medicine · 2025Article
- 9,000 years of genetic continuity in southernmost Africa demonstrated at Oakhurst rockshelter.Nature ecology & evolution · 2024Article
- Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations.bioRxiv : the preprint server for biology · 2024Article
- Unveiling the population genetic structure of Iranian horses breeds by whole-genome resequencing analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries.Evolutionary bioinformatics online · 2024Article
- Implementation of a genotyped African population cohort, with virtual follow-up: A feasibility study in the Western Cape Province, South Africa.Wellcome open research · 2024Article
- Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.Nature communications · 2023Article
- Linking African ancestral substructure to prostate cancer health disparities.Scientific reports · 2023Article
9 more citing papers are in PubMed but not listed here.
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12 authors.
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Abstract
Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the click-speaking forager peoples of southern Africa, broadly defined as Khoesan. Both intra- (Bantu expansion) and inter-continental migration (European-driven colonization) have resulted in complex patterns of admixture between ancient geographically isolated Khoesan and more recently diverged populations. Using gender-specific analysis and almost 1 million autosomal markers, we determine the significance of estimated ancestral contributions that have shaped five contemporary southern African populations in a cohort of 103 individuals. Limited by lack of available data for homogenous Khoesan representation, we identify the Ju/'hoan (n = 19) as a distinct early diverging human lineage with little to no significant non-Khoesan contribution. In contrast to the Ju/'hoan, we identify ancient signatures of Khoesan and Bantu unions resulting in significant Khoesan- and Bantu-derived contributions to the Southern Bantu amaXhosa (n = 15) and Khoesan !Xun (n = 14), respectively. Our data further suggests that contemporary !Xun represent distinct Khoesan prehistories. Khoesan assimilation with European settlement at the most southern tip of Africa resulted in significant ancestral Khoesan contributions to the Coloured (n = 25) and Baster (n = 30) populations. The latter populations were further impacted by 170 years of East Indian slave trade and intra-continental migrations resulting in a complex pattern of genetic variation (admixture). The populations of southern Africa provide a unique opportunity to investigate the genomic variability from some of the oldest human lineages to the implications of complex admixture patterns including ancient and recently diverged human lineages.
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