Evidence map›Paper›PMID 23516356›Full record

ReviewPLoS pathogens2013

The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology.

Martyn K White, Jennifer Gordon, Kamel Khalili

Open access · goldAbstract readReview
In one paragraph

Review in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  8. Review
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  15. Review
  16. A Broad Application of CRISPR Cas9 in Infectious Diseases of Central Nervous System.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  17. Review
  18. Article
  19. The occurrence of polyomaviruses WUPyV and KIPyV among patients with severe respiratory infections.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Martyn K WhiteDepartment of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA.
Jennifer Gordon
Kamel Khalili
Temple University · US

Funding

Viral Gene Editing and Bioinformatics Core for Institution # 269291P30MH092177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Ilker Kudret Sariyer · 2011 to 2026
$24.9M
Cytokine regulation of JC virus latency and reactivationR01AI077460 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI WHITE, MARTYN K · 2008 to 2016
$3.2M
BAG3 mediates interplay of HIV-1 and JCV in brainR01MH086358 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KHALILI, KAMEL · 2009 to 2013
$1.7M
NIAID NIH HHS R01 AI077460NIMH NIH HHS P30 MH092177NIMH NIH HHS R01 MH086358
6 · The paper itself

Abstract

Since their discovery in 1971, the polyomaviruses JC (JCPyV) and BK (BKPyV), isolated from patients with progressive multifocal leukoencephalopathy and polyomavirus-associated nephropathy, respectively, remained for decades as the only known members of the Polyomaviridae family of viruses of human origin. Over the past five years, the application of new genomic amplification technologies has facilitated the discovery of several novel human polyomaviruses (HPyVs), bringing the present number to 10. These HPyVs share many fundamental features in common such as genome size and organization. Infection by all HPyVs is widespread in the human population, but they show important differences in their tissue tropism and association with disease. Much remains unknown about these new viruses. In this review, we discuss the problems associated with studying HPyVs, such as the lack of culture systems for the new viruses and the gaps in our basic understanding of their biology. We summarize what is known so far about their distribution, life cycle, tissue tropism, their associated pathologies (if any), and future research directions in the field.

Indexed as

AnimalsDisease Models, AnimalGenomicsHumansImmunity, CellularLeukoencephalopathy, Progressive MultifocalOrgan SpecificityPolyomavirusPolyomavirus InfectionsTumor Virus InfectionsVirus LatencyVirus Replication

Identifiers

PMID23516356
PMCPMC3597531
OpenAlexW1968076968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.