ArticlePLoS computational biology2013
Processing of multi-dimensional sensorimotor information in the spinal and cerebellar neuronal circuitry: a new hypothesis.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Brain and spinal cord paired stimulation coupled with locomotor training facilitates motor output in human spinal cord injury.Frontiers in neurology · 2022Article
- Whole Body Coordination for Self-Assistance in Locomotion.Frontiers in neurorobotics · 2022Article
- Article
- Article
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- On the neuronal circuitry mediating L-DOPA-induced dyskinesia.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Computational Principles of Supervised Learning in the Cerebellum.Annual review of neuroscience · 2018Review
- Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia.Annals of clinical and translational neurology · 2018Article
- Intracellular Dynamics in Cuneate Nucleus Neurons Support Self-Stabilizing Learning of Generalizable Tactile Representations.Frontiers in cellular neuroscience · 2018Article
- Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior.Scientific reports · 2017Article
- No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?Cerebellum (London, England) · 2017Article
- Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex.Cerebellum (London, England) · 2017Article
- Cerebellar physiology: links between microcircuitry properties and sensorimotor functions.The Journal of physiology · 2017Review
- Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans.Neural plasticity · 2017Article
- Cerebellar-inspired algorithm for adaptive control of nonlinear dielectric elastomer-based artificial muscle.Journal of the Royal Society, Interface · 2016Article
- Paired associative transspinal and transcortical stimulation produces plasticity in human cortical and spinal neuronal circuits.Journal of neurophysiology · 2016Article
- Hand synergies: Integration of robotics and neuroscience for understanding the control of biological and artificial hands.Physics of life reviews · 2016Review
- Cerebellar Synaptic Plasticity and the Credit Assignment Problem.Cerebellum (London, England) · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Why are sensory signals and motor command signals combined in the neurons of origin of the spinocerebellar pathways and why are the granule cells that receive this input thresholded with respect to their spike output? In this paper, we synthesize a number of findings into a new hypothesis for how the spinocerebellar systems and the cerebellar cortex can interact to support coordination of our multi-segmented limbs and bodies. A central idea is that recombination of the signals available to the spinocerebellar neurons can be used to approximate a wide array of functions including the spatial and temporal dependencies between limb segments, i.e. information that is necessary in order to achieve coordination. We find that random recombination of sensory and motor signals is not a good strategy since, surprisingly, the number of granule cells severely limits the number of recombinations that can be represented within the cerebellum. Instead, we propose that the spinal circuitry provides useful recombinations, which can be described as linear projections through aspects of the multi-dimensional sensorimotor input space. Granule cells, potentially with the aid of differentiated thresholding from Golgi cells, enhance the utility of these projections by allowing the Purkinje cell to establish piecewise-linear approximations of non-linear functions. Our hypothesis provides a novel view on the function of the spinal circuitry and cerebellar granule layer, illustrating how the coordinating functions of the cerebellum can be crucially supported by the recombinations performed by the neurons of the spinocerebellar systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.