ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Synaptic mechanisms underlying functional dichotomy between intrinsic-bursting and regular-spiking neurons in auditory cortical layer 5.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed.
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Distinct topographic organization and network activity patterns of corticocollicular neurons within layer 5 auditory cortex.Frontiers in neural circuits · 2023Article
- Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex.Neuron · 2022Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Differences in temporal processing speeds between the right and left auditory cortex reflect the strength of recurrent synaptic connectivity.PLoS biology · 2022Article
- A Novel Layer 4 Corticofugal Cell Type/Projection Involved in Thalamo-Cortico-Striatal Sensory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Urethane Improves the Response of Auditory Neurons to Tone.Frontiers in cellular neuroscience · 2022Article
- Corticostriatal control of defense behavior in mice induced by auditory looming cues.Nature communications · 2021Article
- Network and cellular mechanisms underlying heterogeneous excitatory/inhibitory balanced states.The European journal of neuroscience · 2020Article
- An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex.Frontiers in neural circuits · 2020Article
- Auditory Long-Range Parvalbumin Cortico-Striatal Neurons.Frontiers in neural circuits · 2020Article
- Optimal Pipette Resistance, Seal Resistance, and Zero-Current Membrane Potential for Loose Patch or Breakthrough Whole-Cell RecordingFrontiers in neural circuits · 2020Article
- Synaptic mechanisms underlying the intense firing of neocortical layer 5B pyramidal neurons in response to cortico-cortical inputs.Brain structure & function · 2019Article
- Selective Strengthening of Intracortical Excitatory Input Leads to Receptive Field Refinement during Auditory Cortical Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- A Layer-specific Corticofugal Input to the Mouse Superior Colliculus.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
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5 authors.
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Abstract
Corticofugal projections from the primary auditory cortex (A1) have been shown to play a role in modulating subcortical processing. However, functional properties of the corticofugal neurons and their synaptic circuitry mechanisms remain unclear. In this study, we performed in vivo whole-cell recordings from layer 5 (L5) pyramidal neurons in the rat A1 and found two distinct neuronal classes according to their functional properties. Intrinsic-bursting (IB) neurons, the L5 corticofugal neurons, exhibited early and rather unselective spike responses to a wide range of frequencies. The exceptionally broad spectral tuning of IB neurons was attributable to their broad excitatory inputs with long temporal durations and inhibitory inputs being more narrowly tuned than excitatory inputs. This uncommon pattern of excitatory-inhibitory interplay was attributed initially to a broad thalamocortical convergence onto IB neurons, which also receive temporally prolonged intracortical excitatory input as well as feedforward inhibitory input at least partially from more narrowly tuned fast-spiking inhibitory neurons. In contrast, regular-spiking neurons, which are mainly corticocortical, exhibited sharp frequency tuning similar to L4 pyramidal cells, underlying which are well-matched purely intracortical excitation and inhibition. The functional dichotomy among L5 pyramidal neurons suggests two distinct processing streams. The spectrally and temporally broad synaptic integration in IB neurons may ensure robust feedback signals to facilitate subcortical function and plasticity in a general manner.
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