ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Myo-cortical crossed feedback reorganizes primate motor cortex output.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of brain-computer interface based training on post-stroke upper-limb rehabilitation: a meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- No evidence of neural adaptations following chronic unilateral isometric training of the intrinsic muscles of the hand: a randomized controlled study.European journal of applied physiology · 2016Trial
- Pathological changes of brain oscillations following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation.Frontiers in neuroscience · 2021Article
- Cortical Stimulation Paired With Volitional Unimanual Movement Affects Interhemispheric Communication.Frontiers in neuroscience · 2021Article
- A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates.Journal of visualized experiments : JoVE · 2020Article
- Somatosensory cortical excitability changes precede those in motor cortex during human motor learning.Journal of neurophysiology · 2019Article
- Cortical Stimulation Induces Network-Wide Coherence Change In Non-Human Primate Somatosensory CortexAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019Article
- Article
- Recruitment of Additional Corticospinal Pathways in the Human Brain with State-Dependent Paired Associative Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Paired Stimulation for Spike-Timing-Dependent Plasticity in Primate Sensorimotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Correlation-based model of artificially induced plasticity in motor cortex by a bidirectional brain-computer interface.PLoS computational biology · 2017Article
- Brain-computer interfaces for communication and rehabilitation.Nature reviews. Neurology · 2016Review
- Plastic Changes in Human Motor Cortical Output Induced by Random but not Closed-Loop Peripheral Stimulation: the Curse of Causality.Frontiers in human neuroscience · 2016Article
- Erratum to: Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Article
- Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Review
- Rehabilitation: Boost for movement.Nature · 2015Article
- Targeted, activity-dependent spinal stimulation produces long-lasting motor recovery in chronic cervical spinal cord injury.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Volitional walking via upper limb muscle-controlled stimulation of the lumbar locomotor center in man.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The motor system is capable of adapting to changed conditions such as amputations or lesions by reorganizing cortical representations of peripheral musculature. To investigate the underlying mechanisms we induced targeted reorganization of motor output effects by establishing an artificial recurrent connection between a forelimb muscle and an unrelated site in the primary motor cortex (M1) of macaques. A head-fixed computer transformed forelimb electromyographic activity into proportional subthreshold intracortical microstimulation (ICMS) during hours of unrestrained volitional behavior. This conditioning paradigm stimulated the cortical site for a particular muscle in proportion to activation of another muscle and induced robust site- and input-specific reorganization of M1 output effects. Reorganization was observed within 25 min and could be maintained with intermittent conditioning for successive days. Control stimulation that was independent of muscle activity, termed "pseudoconditioning," failed to produce reorganization. Preconditioning output effects were gradually restored during volitional behaviors following the end of conditioning. The ease of changing the relationship between cortical sites and associated muscle responses suggests that under normal conditions these relations are maintained through physiological feedback loops. These findings demonstrate that motor cortex outputs may be reorganized in a targeted and sustainable manner through artificial afferent feedback triggered from controllable and readily recorded muscle activity. Such cortical reorganization has implications for therapeutic treatment of neurological injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.