ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A modular enhancer mediates SCRT2 repression of ISLET1 in the spinal cord.Developmental biology · 2025Article
- Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors.Frontiers in neuroscience · 2024Article
- Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells.Neural development · 2023Article
- Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear.Journal of anatomy · 2023Article
- Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion.Developmental neurobiology · 2022Article
- NOCICEPTRA: Gene and microRNA Signatures and Their Trajectories Characterizing Human iPSC-Derived Nociceptor Maturation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Article
- A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation.Nature communications · 2019Article
- A myriad of roles of miR-25 in health and disease.Oncotarget · 2018Review
- MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis.Frontiers in neuroscience · 2018Review
- MicroRNA-Mediated Reprogramming of Somatic Cells into Neural Stem Cells or Neurons.Molecular neurobiology · 2017Review
- Fibroblasts from patients with major depressive disorder show distinct transcriptional response to metabolic stressors.Translational psychiatry · 2015Article
- Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting.Journal of extracellular vesicles · 2015Article
- microRNAs: key triggers of neuronal cell fate.Frontiers in cellular neuroscience · 2014Review
- A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons.Frontiers in molecular neuroscience · 2013Article
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Authors and funding
3 authors.
Funding
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Abstract
During the development of the nervous system the regulation of cell cycle, differentiation, and survival is tightly interlinked. Newly generated neurons must keep cell cycle components under strict control, as cell cycle re-entry leads to neuronal degeneration and death. However, despite their relevance, the mechanisms controlling this process remain largely unexplored. Here we show that Scratch2 is involved in the control of the cell cycle in neurons in the developing spinal cord of the zebrafish embryo. scratch2 knockdown induces postmitotic neurons to re-enter mitosis. Scratch2 prevents cell cycle re-entry by maintaining high levels of the cycle inhibitor p57 through the downregulation of miR-25. Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-entry.
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