ArticleFrontiers in oncology2013
A model of dendritic cell therapy for melanoma.
Article in Frontiers in oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Mathematical Modeling ofBioengineering (Basel, Switzerland) · 2025Article
- Dose optimization of an adjuvanted peptide-based personalized neoantigen melanoma vaccine.PLoS computational biology · 2024Article
- Mathematical Modeling Support for Lung Cancer Therapy-A Short Review.International journal of molecular sciences · 2023Review
- Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system.Materials today. Bio · 2022Review
- Mathematical model of a personalized neoantigen cancer vaccine and the human immune system.PLoS computational biology · 2021Article
- Investigating Optimal Chemotherapy Options for Osteosarcoma Patients through a Mathematical Model.Cells · 2021Article
- Data-Driven Mathematical Model of Osteosarcoma.Cancers · 2021Article
- Cancer immune control dynamics: a clinical data driven model of systemic immunity in patients with metastatic melanoma.BMC bioinformatics · 2021Article
- Mathematical Modelling in Biomedicine: A Primer for the Curious and the Skeptic.International journal of molecular sciences · 2021Review
- Conceptual Analogies Between Multi-Scale Feeding and Feedback Cycles in Supermassive Black Hole and Cancer Environments.Frontiers in oncology · 2021Review
- Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization.Frontiers in cell and developmental biology · 2021Article
- QSP-IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno-Oncology Applications.CPT: pharmacometrics & systems pharmacology · 2020Article
- Computational models of melanoma.Theoretical biology & medical modelling · 2020Review
- The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right.Cancer research · 2019Article
- Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm.Journal of translational medicine · 2019Article
- A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer.The AAPS journal · 2019Article
- Mathematical modeling of tumor-immune cell interactions.Journal of theoretical biology · 2019Review
- A Mathematical Model for DC Vaccine Treatment of Type I Diabetes.Frontiers in physiology · 2019Article
- Dendritic Immunotherapy Improvement for an Optimal Control Murine Model.Computational and mathematical methods in medicine · 2017Article
- Mathematical Models for Immunology: Current State of the Art and Future Research Directions.Bulletin of mathematical biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells are a promising immunotherapy tool for boosting an individual's antigen-specific immune response to cancer. We develop a mathematical model using differential and delay-differential equations to describe the interactions between dendritic cells, effector-immune cells, and tumor cells. We account for the trafficking of immune cells between lymph, blood, and tumor compartments. Our model reflects experimental results both for dendritic cell trafficking and for immune suppression of tumor growth in mice. In addition, in silico experiments suggest more effective immunotherapy treatment protocols can be achieved by modifying dose location and schedule. A sensitivity analysis of the model reveals which patient-specific parameters have the greatest impact on treatment efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.