ArticleProceedings. Biological sciences2013
Deep sequencing reveals complex mechanisms of diapause preparation in the invasive mosquito, Aedes albopictus.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 154 citations in OpenAlex.
- Crosstalk in the cold: host-microbe interactions in insect diapause.Annals of the Entomological Society of America · 2026Review
- Temporal orchestration of transcriptional and epigenomic programming underlying maternal embryonic diapause in a cricket model.Communications biology · 2026Article
- Suppression of transgenerational lipid provisioning inhibits desiccation resistance, but not diapause, in the vector mosquito, Aedes albopictus.Scientific reports · 2026Article
- Suppression of transgenerational lipid provisioning inhibits desiccation resistance, but not diapause, in the vector mosquito, Aedes albopictus.Research square · 2026Article
- Article
- Major changes in gene expression between strains of diapausing and non-diapause spruce budworm.PloS one · 2026Article
- Using diapause as a platform to understand the biology of dormancy.Open biology · 2025Review
- Article
- Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Current research in insect science · 2025Article
- Endocrine and enzymatic shifts during insect diapause: a review of regulatory mechanisms.Frontiers in physiology · 2025Review
- Characterization of pre-diapause phase in the northern Drosophila species D. ezoana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Temperature and photoperiod differentially impact maternal phenotypes in diapause egg-laying Aedes albopictus mosquitoes.PLoS neglected tropical diseases · 2024Article
- Transcription profiling reveals tissue-specific metabolic pathways in the fat body and ovary of the diapausing mosquito Culex pipiens.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2024Article
- Article
- Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism.PLoS biology · 2023Article
- Diapause-Linked Gene Expression Pattern and Related Candidate Duplicated Genes of the Mountain ButterflyInternational journal of molecular sciences · 2023Article
- Aedes albopictus host odor preference does not drive observed variation in feeding patterns across field populations.Scientific reports · 2023Article
- Genomic Shifts, Phenotypic Clines, and Fitness Costs Associated With Cold Tolerance in the Asian Tiger Mosquito.Molecular biology and evolution · 2022Article
- Maternal body condition and season influence RNA deposition in the oocytes of alfalfa leafcutting bees (Frontiers in genetics · 2022Article
- A comparative analysis ofCurrent research in insect science · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Seasonal environments present fundamental physiological challenges to a wide range of insects. Many temperate insects surmount the exigencies of winter by undergoing photoperiodic diapause, in which photoperiod provides a token cue that initiates an alternative developmental programme leading to dormancy. Pre-diapause is a crucial preparatory phase of this process, preceding developmental arrest. However, the regulatory and physiological mechanisms of diapause preparation are largely unknown. Using high-throughput gene expression profiling in the Asian tiger mosquito, Aedes albopictus, we reveal major shifts in endocrine signalling, cell proliferation, metabolism, energy production and cellular structure across pre-diapause development. While some hallmarks of diapause, such as insulin signalling and stress response, were not important at the transcriptional level, two genes, Pepck and PCNA, appear to show diapause-induced transcriptional changes across insect taxa. These processes demonstrate physiological commonalities between Ae. albopictus pre-diapause and diapause strategies across insects, and support the idea of a genetic 'toolkit' for diapause. Observations of gene expression trends from a comparative developmental perspective suggest that individual physiological processes are delayed against a background of a fixed morphological ontogeny. Our results demonstrate how deep sequencing can provide new insights into elusive molecular bases of complex ecological adaptations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.