ArticleAAPS PharmSciTech2013
Drug-loaded zein nanofibers prepared using a modified coaxial electrospinning process.
Article in AAPS PharmSciTech, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Tuning Corn Zein-Chitosan Biocomposites via Mild Alkaline Treatment: Structural and Physicochemical Property Insights.Polymers · 2025Article
- Vitamin E Microencapsulation via Electrohydrodynamic Techniques for Potential Use in Skin Care and Dermatological Applications.Molecules (Basel, Switzerland) · 2025Article
- Silk-Corn Zein Alloy Materials: Influence of Silk Types (Mori, Thai, Muga, Tussah, and Eri) on the Structure, Properties, and Functionality of Insect-Plant Protein Blends.International journal of molecular sciences · 2024Article
- Extraction of Natural-Based Raw Materials Towards the Production of Sustainable Man-Made Organic Fibres.Polymers · 2024Review
- Preparation and Characterization of Zein-Metformin/Gelatin Nanofibers by Coaxial Electrospinning.ACS omega · 2024Article
- Development of Verapamil Hydrochloride-loaded Biopolymer-based Composite Electrospun Nanofibrous Mats: In vivo Evaluation of Enhanced Burn Wound Healing without Scar Formation.Drug design, development and therapy · 2023Article
- Effects of Surfactants on Zein Cast Films for Simultaneous Delivery of Two Hydrophilic Active Components.Materials (Basel, Switzerland) · 2022Article
- Zein as a versatile biopolymer: different shapes for different biomedical applications.RSC advances · 2021Review
- Multifunctional Electrospun Nanofibers Based on Biopolymer Blends and Magnetic Tubular Halloysite for Medical Applications.Polymers · 2021Article
- Air-Spun Silk-Based Micro-/Nanofibers and Thin Films for Drug Delivery.International journal of molecular sciences · 2021Article
- Review on Electrospun Nanofiber-Applied Products.Polymers · 2021Review
- Bio-Based Electrospun Fibers for Wound Healing.Journal of functional biomaterials · 2020Review
- Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review.Pharmaceutics · 2019Review
- Fabrication of Electrospun Polymer Nanofibers with Diverse Morphologies.Molecules (Basel, Switzerland) · 2019Review
- α-Bisabolol-Loaded Cross-Linked Zein Nanofibrous 3D-Scaffolds For Accelerating Wound Healing And Tissue Regeneration In Rats.International journal of nanomedicine · 2019Article
- Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery.Pharmaceutics · 2018Review
- Silver sulfadiazine loaded zein nanofiber mats as a novel wound dressing.RSC advances · 2018Article
- Electrospinning of zein/propolis nanofibers; antimicrobial properties and morphology investigation.Journal of materials science. Materials in medicine · 2018Article
- Protein-Based Fiber Materials in Medicine: A Review.Nanomaterials (Basel, Switzerland) · 2018Review
- Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems.Critical reviews in biotechnology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the preparation of drug-loaded fibers using a modified coaxial electrospinning process, in which only unspinnable solvent was used as sheath fluid. With zein/ibuprofen (IBU) co-dissolving solution and N, N-dimethylformamide as core and sheath fluids, respectively, the drug-loaded zein fibers could be generated continuously and smoothly without any clogging of the spinneret. Field emission scanning electron microscopy and transmission electron microscopy observations demonstrated that the fibers had ribbon morphology with a smooth surface. Their average diameters were 0.94±0.34 and 0.67±0.21 μm when the sheath-to-core flow rate ratios were taken as 0.11 and 0.25, respectively. X-ray diffraction and differential scanning calorimetry verified that IBU was in an amorphous state in all fiber composites. Fourier transform infrared spectra showed that zein had good compatibility with IBU owing to hydrogen bonding. In vitro dissolution tests showed that all the fibers could provide sustained drug release files via a typical Fickian diffusion mechanism. The modified coaxial electrospinning process reported here can expand the capability of electrospinning in generating fibers and provides a new manner for developing novel drug delivery systems.
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Registered trials
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