ArticleInternational journal of colorectal disease2013
Appendicopathy--a clinical and diagnostic dilemma.
Article in International journal of colorectal disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Neurogenic appendicopathy: an underestimated disease-systematic review of the literature.International journal of colorectal disease · 2021Pooled it
- Neurogenic Appendicopathy in Pediatric Appendectomies During the COVID-19 Era: A Retrospective Analysis of Histologically Negative Cases.International journal of pediatrics · 2026Article
- An Imitator Within: A Case of Appendiceal Neuroma Masquerading as Chronic Appendicitis.Cureus · 2025Article
- Noninflammatory obstructive appendicopathy: A rare presentation of abdominal pain.Clinical case reports · 2023Article
- Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis.Diagnostics (Basel, Switzerland) · 2022Review
- Differences between inflamed and non inflamed appendices diagnosed as acute appendicitis.Annals of medicine and surgery (2012) · 2021Article
- Unusual Entities of Appendix Mimicking Appendicitis Clinically - Emphasis on Diagnosis and Treatment.Maedica · 2017Article
- The continuing dilemma of chronic appendicitis.Therapeutic advances in gastroenterology · 2015Article
- Laparoscopic appendectomy for chronic right lower quadrant abdominal pain.International journal of colorectal disease · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe term "neurogenic appendicopathy" has been used for patients operated on for acute appendicitis with their appendices lacking signs of acute inflammation. The aim of this retrospective study was to clarify the presence of potential neurogenic appendicopathies, analyzing patients' clinical symptoms and their corresponding appendiceal specimens.
methodsOne hundred twenty-one patients were identified showing a histological diagnosis of chronic appendicitis. Eventually, 40 patients qualified for the potential diagnosis "neurogenic appendicopathy." Appendix specimens were immunohistochemically examined for the expression of S-100, vasoactive intestinal polypeptide (VIP), and substance P. Controls consisted of 110 patients with acute appendicitis and 120 patients following appendectomies operated on for other reasons.
resultsEventually, 40 of 120 patients qualified for the potential diagnosis "neurogenic appendicopathy." Compared to patients with acute appendicitis, there was only little difference in clinical symptoms. Histologically, neuromas, thought of being characteristic of neurogenic appendicopathy, were demonstrated significantly more often in the control group (p = 0.01). S-100 was significantly more expressed in the appendicopathy group (p = 0.0024), but nearly 50% of control specimens showed an intense staining, too. S-100(+) neurofibers were significantly (p = 0.00122) more often found in the mucosa of appendicopathy specimens, but this was true for only 25% of specimens. VIP was more strongly expressed in control specimens (p = 0.0211). Substance P was of no diagnostic value.
conclusionsOur study could not confirm the neurogenic origin of appendicopathies. Yet, clinical data strongly suggest the existence of the entity "appendicopathy." Therefore, we suggest removing a macroscopically unaffected appendix in patients with appendicitis-like symptoms if, on laparoscopy, no other cause can be found.
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