Evidence map›Paper›PMID 23516066›Full record

ArticleJournal of the Royal Society, Interface2013

Multidomain and ground state configurations of two-phase vesicles.

Mohsen Maleki, Eliot Fried

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mohsen MalekiDepartment of Mechanical Engineering, McGill University, Montréal, QC, Canada.
Eliot Fried

Funding

DYNAMICS OF NANOSCALE LIPID DOMAINSR01GM084200 · NIGMS · WASHINGTON UNIVERSITY · PI ELSON, ELLIOT L. · 2008 to 2011
$1.2M
NIGMS NIH HHS GM084200NIGMS NIH HHS R01 GM084200
6 · The paper itself

Abstract

A simple model is used to study the equilibrium of lipid domains on two-phase vesicles. Two classes of configurations are considered: multidomain and ground state configurations. For multidomain configurations, the vesicle has a finite number of identical lipid domains. For ground state configurations, the vesicle is fully phase separated into two coexisting domains. Whereas the volume enclosed by a vesicle with multidomains is fixed, the volume enclosed by a vesicle in a ground state is allowed to vary with the osmotic pressure. Guided by experimental observations, all domains are assumed to be spherical caps. In a multidomain configuration, the line tension is found to decrease with the number of domains present, with possible exceptions when the number of domains is very small. The importance of a critical osmotic pressure and a critical excess radius on ground state configurations is explored. Emphasis is placed on understanding the variations of these critical quantities with relevant parameters.

Indexed as

Models, BiologicalCell MembraneLipid BilayersMembrane MicrodomainsOsmotic PressureTransport VesiclesLipid Bilayers

Identifiers

PMID23516066
PMCPMC3645419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.