ArticleCellular and molecular neurobiology2013
Decreased glucokinase protein expression in the aged gerbil hippocampus.
Article in Cellular and molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia.Endocrine reviews · 2019Review
- Remote control of glucose-sensing neurons to analyze glucose metabolism.American journal of physiology. Endocrinology and metabolism · 2018Review
- Insights into the role of neuronal glucokinase.American journal of physiology. Endocrinology and metabolism · 2016Review
- Increased dynamin-1 and -2 protein expression in the aged gerbil hippocampus.Cellular and molecular neurobiology · 2014Article
- Decreased insulin-like growth factor-I and its receptor expression in the hippocampus and somatosensory cortex of the aged mouse.Neurochemical research · 2014Article
- Time-course changes in immunoreactivities of glucokinase and glucokinase regulatory protein in the gerbil hippocampus following transient cerebral ischemia.Neurochemical research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucokinase (GK) and its regulatory protein (GKRP) play roles in glucose utilization as well as glucose-sensing process in the brain. In the present study, we compared GK and GKRP protein expressions in the hippocampus of adult (postnatal month 6) and aged (postnatal month 24) gerbils using immunohistochemistry and western blot analysis. Both GK and GKRP immunoreactivities were observed primarily in the pyramidal cells of the hippocampus proper and in the granule cells of the dentate gyrus of the adult and aged hippocampus. GK, not GKRP, immunoreactivity was apparently decreased in the pyramidal and granule cells of the aged group compared with that in the adult group. In addition, western blot analysis also showed that the GK, not GKRP, protein level was significantly decreased in the aged hippocampus. These results indicate that the decrease of GK may be closely related to the reduction of glucose utilization and uptake, although the ability for regulation of GK is maintained in the aged hippocampus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.