ArticleInternational urology and nephrology2014
Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation.
Article in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- A Critical Role of Neutrophil-Driven Amplification of Chronic Microinflammation in the Biocompatibility of Hemodialysis.International journal of molecular sciences · 2025Review
- Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.Molecular and cellular biochemistry · 2021Review
- Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass.Journal of cardiothoracic surgery · 2020Article
- Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation.International journal of molecular sciences · 2020Review
- Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside.Oxidative medicine and cellular longevity · 2019Review
- Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases.Frontiers in immunology · 2018Review
- Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia.Scientific reports · 2017Article
- Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage.Frontiers in immunology · 2016Review
- NRF2 and NF-κB mRNA expression in chronic kidney disease: a focus on nondialysis patients.International urology and nephrology · 2015Article
- Regulation of mitochondrial biogenesis and its intersection with inflammatory responses.Antioxidants & redox signaling · 2015Review
- Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging.Redox biology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInflammation is common in hemodialysis (HD) patients. Mitochondrial damage-associated molecular patterns (DAMPs) are released during cell necrosis or apoptosis and induce inflammation. Cell apoptosis is increased in HD patients. The mitochondrial protein cytochrome c, as a marker of released mitochondrial DAMPs, and interleukin-6 (IL-6), as a marker of inflammation, were evaluated in HD patients.
methodsThirty-four HD patients and 20 controls were enrolled in the study. Serum cytochrome c and IL-6 were measured by means of enzyme-linked immunosorbent assay.
resultsCompared to controls, cytochrome c was markedly increased in HD patients (1392.88 ± 905.24 pg/mL vs. 212.95 ± 91.71 pg/mL). IL-6 was also significantly increased in HD patients (50.32 ± 35.89 pg/mL vs. 14.27 ± 6.83 pg/mL). In HD patients serum IL-6 was positively related to serum cytochrome c (r = 0.458).
conclusionBoth circulating cytochrome c and IL-6 are markedly increased in HD patients. Cytochrome c is positively related to IL-6.
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