ArticleJournal of bone and mineral metabolism2013
Vertebral bone density by quantitative computed tomography mirrors bone structure histomorphometric parameters in hemodialysis patients.
Article in Journal of bone and mineral metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Use of 3D-DXA in the assessment of bone structure among patients with chronic kidney disease.Frontiers in medicine · 2025Article
- Cortical bone density by quantitative computed tomography mirrors disorders of bone structure in bone biopsy of non-dialysis CKD patients.Bone reports · 2022Article
- Cortical unlike trabecular bone loss is not associated with vascular calcification progression in CKD patients.BMC nephrology · 2020Article
- The unexpected presence of iron in bone biopsies of hemodialysis patients.International urology and nephrology · 2018Article
- Diagnosis of low bone mass in CKD-5D patients.Clinical nephrology · 2016Article
- Evaluating bone quality in patients with chronic kidney disease.Nature reviews. Nephrology · 2013Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
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Abstract
Diagnosing low bone mass is of clinical importance for hemodialysis (HD) patients due to its association with fractures and cardiovascular disease. We investigated whether bone density obtained by quantitative computed tomography (QCT) is associated with the histologically determined bone volume and microarchitecture parameters in HD patients. Twenty-six HD patients were studied. Bone biopsy samples were obtained from the iliac crest and trabecular bone volume, thickness, number and separation were evaluated by histomorphometry. Vertebral trabecular bone density (VTBD) was evaluated by QCT. VTBD correlated positively with trabecular bone volume (r = 0.69, p < 0.001), trabecular thickness (r = 0.45, p = 0.022) and trabecular number (r = 0.62, p < 0.001), and negatively with trabecular separation (r = -0.50, p < 0.01). In the multiple linear regression analysis adjusting for age, gender and diabetes, VTBD remained associated with bone volume by histomorphometry (β = 0.06; 95 % CI 0.02-0.11; p = 0.006; R² = 0.49). VTBD measured by QCT mirrored bone volume and microarchitecture parameters obtained by histomorphometry in HD patients.
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