ArticleAmerican journal of physiology. Renal physiology2013
The emerging role of MRI in quantitative renal glomerular morphology.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Innovative Technologies for Kidney Research: Three-Dimensional Imaging and Quantification.Seminars in nephrology · 2026Review
- Opportunistic Detection of Chronic Kidney Disease Using CT-Based Measurements of Kidney Volume and Perirenal Fat.Journal of clinical medicine · 2025Article
- Physiological principles underlying the kidney targeting of renal nanomedicines.Nature reviews. Nephrology · 2024Review
- In-vivo evaluation of molybdenum as bioabsorbable stent candidate.Bioactive materials · 2022Article
- An Introduction to Stereology with Applications to the Glomerulus.Glomerular diseases · 2021Review
- In vivo measurements of kidney glomerular number and size in healthy and OsAmerican journal of physiology. Renal physiology · 2019Article
- How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?Physiology (Bethesda, Md.) · 2019Review
- Stereological study of developing glomerular forms during human fetal kidney development.Pediatric nephrology (Berlin, Germany) · 2018Article
- Complications during pregnancy and fetal development: implications for the occurrence of chronic kidney disease.Expert review of cardiovascular therapy · 2017Review
- Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger.Nanoscale · 2017Review
- MRI tools for assessment of microstructure and nephron function of the kidney.American journal of physiology. Renal physiology · 2016Review
- Predicted consequences of diabetes and SGLT inhibition on transport and oxygen consumption along a rat nephron.American journal of physiology. Renal physiology · 2016Article
- Efficient Small Blob Detection Based on Local Convexity, Intensity and Shape Information.IEEE transactions on medical imaging · 2016Article
- Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury.Pediatric research · 2016Article
- Phenotyping by magnetic resonance imaging nondestructively measures glomerular number and volume distribution in mice with and without nephron reduction.Kidney international · 2016Article
- Counting glomeruli and podocytes: rationale and methodologies.Current opinion in nephrology and hypertension · 2015Review
- Current MRI techniques for the assessment of renal disease.Current opinion in nephrology and hypertension · 2015Review
- Ferritins as nanoplatforms for imaging and drug delivery.Expert opinion on drug delivery · 2014Review
- Live nephron imaging by MRI.American journal of physiology. Renal physiology · 2014Article
- Glomerular hypertrophy in subjects with low nephron number: contributions of sex, body size and race.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Techniques to measure morphological parameters, such as glomerular (and thereby nephron) number, glomerular size, and kidney volume, have been vital to understanding factors contributing to chronic kidney disease (CKD). These techniques have also been important to understanding the associations between CKD and other systemic and cardiovascular diseases and have led to the identification of developmental risk factors for these pathologies. However, existing techniques in quantitative kidney morphology are resource- and time-consuming and are destructive to the organ. This review discusses the emerging generation of techniques to study kidney morphology quantitatively using magnetic resonance imaging (MRI) using the intravenous injection of the superparamagnetic nanoparticle cationic ferritin, which binds to the glomerular basement membrane. A primary advantage of MRI over previously established techniques is the ability to quantify morphology in the intact organ with minimal sample preparation. We highlight areas of research where MRI-based morphological measurements will be helpful in animal models and possibly diagnostic clinical nephrology, discuss technical challenges in light of the progress in MRI techniques to date, and identify novel measurements that may be possible using MRI, both ex vivo and in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.