ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Systemic and vastus lateralis muscle blood flow and O2 extraction during ramp incremental cycle exercise.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Muscle O2 extraction reserve during intense cycling is site-specific.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Trial
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- Assessing the feasibility of near-infrared spectroscopy for evaluating physiological exercise thresholds.Scientific reports · 2025Article
- Altered cardiac contractility and aerobic muscular capacity markers during exercise in patients with obesity and DMT II.BMC sports science, medicine & rehabilitation · 2025Article
- The relationship and agreement between systemic and local breakpoints in locomotor and non-locomotor muscles during single-leg cycling.Frontiers in physiology · 2025Article
- Evaluation of leg symmetry in muscle oxygen saturation during submaximal to maximal cycling exercise.European journal of sport science · 2025Article
- Profiles of muscle-specific oxygenation responses and thresholds during graded cycling incremental test.European journal of applied physiology · 2025Article
- Effect of Curcumin Intake on Skeletal Muscle Oxygen Saturation Parameters in Older Participants.Antioxidants (Basel, Switzerland) · 2024Article
- Agreement between Ventilatory Thresholds and Bilaterally Measured Vastus Lateralis Muscle Oxygen Saturation Breakpoints in Trained Cyclists: Effects of Age and Performance.Sports (Basel, Switzerland) · 2024Article
- AltitudeOmics: effects of 16 days acclimatization to hypobaric hypoxia on muscle oxygen extraction during incremental exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Differential impact of heat and hypoxia on dynamic oxygen uptake and deoxyhemoglobin parameters during incremental exhaustive exercise.Frontiers in physiology · 2023Article
- The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness.Frontiers in physiology · 2023Review
- A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review.International journal of environmental research and public health · 2022Review
- Impact of supine versus upright exercise on muscle deoxygenation heterogeneity during ramp incremental cycling is site specific.European journal of applied physiology · 2021Article
- Muscle Oxygen Desaturation and Re-Saturation Capacity Limits in Repeated Sprint Ability Performance in Women Soccer Players: A New Physiological Interpretation.International journal of environmental research and public health · 2021Article
- The Estimation of Critical Angle in Climbing as a Measure of Maximal Metabolic Steady State.Frontiers in physiology · 2021Article
- Muscle cooling modulates tissue oxidative and biochemical responses but not energy metabolism during exercise.European journal of applied physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During ramp incremental cycling exercise increases in pulmonary O2 uptake (Vo2p) are matched by a linear increase in systemic cardiac output (Q). However, it has been suggested that blood flow in the active muscle microvasculature does not display similar linearity in blood flow relative to metabolic demand. This study simultaneously examined both systemic and regional (microvascular) blood flow and O2 extraction during incremental cycling exercise. Ten young men (Vo2 peak = 4.2 ± 0.5 l/min) and 10 young women (Vo2 peak = 3.2 ± 0.5 l/min) were recruited to perform two maximal incremental cycling tests on separate days. The acetylene open-circuit technique and mass spectrometry and volume turbine were used to measure Q (every minute) and breath-by-breath Vo2p, respectively; systemic arterio-venous O2 difference (a-vO2diff) was calculated as Vo2p/Q on a minute-by-minute basis. Changes in near-infrared spectroscopy-derived muscle deoxygenation (Δ[HHb]) were used (in combination with Vo2p data) to estimate the profiles of peripheral O2 extraction and blood flow of the active muscle microvasculature. The systemic Q-to-Vo2p relationship was linear (~5.8 l/min increase in Q for a 1 l/min increase in Vo2p) with a-vO2diff displaying a hyperbolic response as exercise intensity increased toward Vo2 peak. The peripheral blood flow response profile was described by an inverted sigmoid curve, indicating nonlinear responses relative to metabolic demand. The Δ[HHb] profile increased linearly with absolute Vo2p until high-intensity exercise, thereafter displaying a "near-plateau". Results indicate that systemic blood flow and thus O2 delivery does not reflect the profile of blood flow changes at the level of the microvasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.