ArticleJournal of clinical microbiology2013
A continuous bovine kidney cell line constitutively expressing bovine αvβ6 integrin has increased susceptibility to foot-and-mouth disease virus.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
94 citing papers in PubMed, 149 citations in OpenAlex.
- Phylogenetic Analysis of Foot-and-Mouth Disease Virus from Cattle in Nigeria, 2017-2020.Viruses · 2026Article
- Attenuation without protective immunogenicity: effects of codon-pair deoptimization on foot-and-mouth disease virus serotype O in swine.Scientific reports · 2026Article
- Environmental Sampling Using Shoe Booties for the Detection of Foot and Mouth Disease Virus in Animal Pens.Viruses · 2026Article
- Absence of a dose-response relationship after intra-oropharyngeal inoculation of pigs with foot-and-mouth disease virus serotype O.Veterinary research · 2026Article
- Live-attenuated foot-and-mouth disease virus vaccine engineered by codon deoptimization induces a strong protective immune response in cattle.NPJ vaccines · 2026Article
- Incubation phase transmission of foot-and-mouth disease virus in cattle: experimental evidence and simulated impacts.Scientific reports · 2026Article
- Improved method for elimination of bovine viral diarrhea virus from contaminated cell lines using virus inhibitor DB772.The Journal of veterinary medical science · 2025Article
- Near complete genome sequences of 12 foot-and-mouth disease viruses of serotype O, isolated from cattle in eastern and northern Uganda between 2014 and 2017.Microbiology resource announcements · 2025Article
- Highly suitable LFBK cells for African swine fever virus replication and type I interferon-induced immune studies.Veterinary research · 2025Article
- Differential mosaicism of recombinant foot-and-mouth disease viruses resulting from heterologous superinfection of cattle.Journal of virology · 2025Article
- Distinct mutations emerge in the genome of serotype O foot-and-mouth disease virus during persistence in cattle.Journal of virology · 2025Article
- Phylogenetic Characterization and Pathogenicity in Cattle and Pigs of Foot-and-Mouth Disease Viruses Circulating in Myanmar Between 2016 and 2022.Transboundary and emerging diseases · 2025Article
- Comparative analysis of VP1 epitopic variation among different isolates of foot-and-mouth disease virus type-O during an outbreak in the Punjab province of Pakistan.Veterinary research forum : an international quarterly journal · 2025Article
- Review
- Leaderless foot-and-mouth disease virus serotype O did not cause clinical disease and failed to establish a persistent infection in cattle.Emerging microbes & infections · 2024Article
- Review
- Effect of doubled dose administration of foot-and-mouth disease vaccine against heterologous virus infection in cattle.The Journal of veterinary medical science · 2024Article
- Foot and Mouth Disease Vaccine Matching and Post-Vaccination Assessment in Abu Dhabi, United Arab Emirates.Veterinary sciences · 2024Article
- Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Emirate of Abu Dhabi, United Arab Emirates.Veterinary sciences · 2024Article
- Detection of foot-and-mouth disease virus RNA using a closed loop-mediated isothermal amplification system.Frontiers in microbiology · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and their products from affected countries. The rapid isolation, serotyping, and vaccine matching of FMD virus from disease outbreaks is critical for enabling the implementation of effective vaccination programs and to stop the spread of infection during outbreaks. Some primary cells have been shown to be highly susceptible to most strains of FMD virus (FMDV) but are difficult and expensive to prepare and maintain. Since the αVβ6 integrin is a principal receptor for FMDV, we transduced a bovine kidney cell line to stably express both the αV and β6 bovine integrin subunits. This stable cell line (LFBK-αVβ6) showed β6 expression and enhanced susceptibility to FMDV infection for ≥ 100 cell passages. LFBK-αVβ6 cells were highly sensitive for detecting all serotypes of FMDV from experimentally infected animals, including the porcinophilic FMDV strain O/TAW/97. In comparison to other cell types that are currently used for virus isolation, LFBK-αVβ6 cells were more effective at detecting FMDV in clinical samples, supporting their use as a more sensitive tool for virus isolation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.