Evidence map›Paper›PMID 23515539›Full record

ArticleJournal of clinical microbiology2013

Evaluation of the fully automated BD MAX Cdiff and Xpert C. difficile assays for direct detection of Clostridium difficile in stool specimens.

Alexander H Dalpke, Marjeta Hofko, Markus Zorn, Stefan Zimmermann

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Evaluation of the Cepheid Xpert C. difficile diagnostic assay: an update meta-analysis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021
    Pooled it
  2. Pooled it
  3. Comparative evaluation of the STANDARD M10 and XpertJournal of clinical microbiology · 2024
    Article
  4. Review
  5. Article
  6. Comparison of commercial assays and two-step approach to detectAfrican journal of laboratory medicine · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Role of Pneumocystis jirovecii in patients with different pulmonary underlying condition using a nested-PCR.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Combination of culture, antigen and toxin detection, and cytotoxin neutralization assay for optimal Clostridium difficile diagnostic testing.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander H DalpkeDepartment of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital Heidelberg, Heidelberg, Germany. alexander.dalpke@med.uni-heidelberg.de
Marjeta Hofko
Markus Zorn
Stefan Zimmermann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the fully automated molecular BD MAX Cdiff assay (BD Diagnostics) and the Xpert C. difficile test (Cepheid) for rapid detection of Clostridium difficile infection. Culture was done on chromogenic agar followed by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry identification and toxin detection. Repeat testing was required for 1.8% and 6.0% of the BD MAX and Xpert tests, respectively. Sensitivities, specificities, positive predictive values (PPV), and negative predictive values (NPV) were 90.5%, 97.9%, 89.3%, and 98.1%, respectively, for BD MAX and 97.3%, 97.9%, 90.0%, and 99.5%, respectively, for Xpert.

Indexed as

Automation, LaboratoryBacterial ToxinsBacteriological TechniquesChromogenic CompoundsClostridioides difficileClostridium InfectionsCulture MediaFecesHumansMolecular Diagnostic TechniquesPredictive Value of TestsSensitivity and SpecificitySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBacterial ToxinsChromogenic CompoundsCulture Media

Identifiers

PMID23515539
PMCPMC3716071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.