ArticleThe Journal of clinical endocrinology and metabolism2013
Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- The association between body mass index and osteoporosis, with consideration of sex differences: a systematic review and dose-response meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- A meta-analysis of the association between body mass index and risk of vertebral fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SBD111, for the clinical dietary management of bone loss in menopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Trial
- Bone quality response to lifestyle intervention in older adults with obesity (LIMB-Q trial): a randomised controlled trial.The lancet. Healthy longevity · 2025Trial
- Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Trial
- Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.Hormone research in paediatrics · 2019Trial
- Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia.Journal of bone and mineral metabolism · 2017Trial
- Vertebral Strength and Estimated Fracture Risk Across the BMI Spectrum in Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Trial
- Potential Role for the Ubiquitin Ligase SIAH2 in Modulating Bone Morphology and Adiposity.Calcified tissue international · 2026Article
- Beyond Weight Loss: Skeletal Considerations in Obesity Treatment.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- Association of high-density lipoprotein with P1NP and β-CTX in hospitalized patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- The Effects of Obesity and Weight Loss Interventions on Bone Health: A Narrative Review.Current diabetes reports · 2025Review
- Effects of a high-fat diet on gut microbiota and possible implications for bone health in male Wistar rats.Lipids · 2025Article
- Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy.Open forum infectious diseases · 2025Article
- Bone Health in Metabolic Syndrome-Is It a Neglected Aspect of Dysmetabolic-Related Diseases?Journal of clinical medicine · 2025Review
- Central obesity is more strongly associated with vertebral fractures than general obesity: a cross-sectional study.BMC geriatrics · 2025Article
- Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines.Open forum infectious diseases · 2025Article
- Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients.World journal of diabetes · 2025Article
- Low Bone Turnover, Mineralization Impairment, and Cortical Alterations in Patients with Axial Spondyloarthritis: A Histomorphometric Study.Calcified tissue international · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 2 countries.
Funding
Abstract
contextThe conventional view that obesity is beneficial for bone strength has recently been challenged by studies that link obesity, particularly visceral obesity, to low bone mass and fractures. It is controversial whether effects of obesity on bone are mediated by increased bone resorption or decreased bone formation.
objectiveThe objective of the study was to evaluate bone microarchitecture and remodeling in healthy premenopausal women of varying weights.
designWe measured bone density and trunk fat by dual-energy x-ray absorptiometry in 40 women and by computed tomography in a subset. Bone microarchitecture, stiffness, remodeling, and marrow fat were assessed in labeled transiliac bone biopsies.
resultsBody mass index (BMI) ranged from 20.1 to 39.2 kg/m(2). Dual-energy x-ray absorptiometry-trunk fat was directly associated with BMI (r = 0.78, P < .001) and visceral fat by computed tomography (r = 0.79, P < .001). Compared with women in the lowest tertile of trunk fat, those in the highest tertile had inferior bone quality: lower trabecular bone volume (20.4 ± 5.8 vs 29.1 ± 6.1%; P = .001) and stiffness (433 ± 264 vs 782 ± 349 MPa; P = .01) and higher cortical porosity (8.8 ± 3.5 vs 6.3 ± 2.4%; P = .049). Bone formation rate (0.004 ± 0.002 vs 0.011 ± 0.008 mm(2)/mm · year; P = .006) was 64% lower in the highest tertile. Trunk fat was inversely associated with trabecular bone volume (r = -0.50; P < .01) and bone formation rate (r = -0.50; P < .001). The relationship between trunk fat and bone volume remained significant after controlling for age and BMI.
conclusionsAt the tissue level, premenopausal women with more central adiposity had inferior bone quality and stiffness and markedly lower bone formation. Given the rising levels of obesity, these observations require further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.