ArticleFrontiers in genetics2013
An f2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: design and genetic parameters.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Genome-Wide Association Studies Reveal Key Candidate Genes for Egg Weight and Quality Components in an FVeterinary sciences · 2026Article
- Genome-Wide Association Studies of Body Weight and Average Daily Gain in Chinese Dongliao Black Pigs.International journal of molecular sciences · 2025Article
- Identification of Signatures of Positive Selection That Have Shaped the Genomic Landscape of South African Pig Populations.Animals : an open access journal from MDPI · 2024Article
- Obesity Animal Models for Acupuncture and Related Therapy Research Studies.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Phenotyping of the Visceral Adipose Tissue Using Dual Energy X-Ray Absorptiometry (DXA) and Magnetic Resonance Imaging (MRI) in Pigs.Animals : an open access journal from MDPI · 2020Article
- "Sex" and body region effects on bone mineralization in male pigs.Archives animal breeding · 2020Article
- An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits.Frontiers in genetics · 2019Article
- Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism.Frontiers in genetics · 2019Article
- Deregulation of obesity-relevant genes is associated with progression in BMI and the amount of adipose tissue in pigs.Molecular genetics and genomics : MGG · 2018Article
- Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.PloS one · 2017Article
- A GWA study reveals genetic loci for body conformation traits in Chinese Laiwu pigs and its implications for human BMI.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Hepatic expression of inflammatory genes and microRNAs in pigs with high "cholesteryl ester transfer protein" (CETP) activity.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes.BMC genomics · 2016Article
- Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity.Journal of diabetes research · 2016Article
- Expression study of GLUT4 translocation-related genes in a porcine pre-diabetic model.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- An integrative systems genetics approach reveals potential causal genes and pathways related to obesity.Genome medicine · 2015Article
- Non-invasive methods for the determination of body and carcass composition in livestock: dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging and ultrasound: invited review.Animal : an international journal of animal bioscience · 2015Article
- Gender and Obesity Specific MicroRNA Expression in Adipose Tissue from Lean and Obese Pigs.PloS one · 2015Article
- Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.PloS one · 2015Article
- Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Genetics, selection, evolution : GSE · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a rising worldwide public health problem. Difficulties to precisely measure various obesity traits and the genetic heterogeneity in human have been major impediments to completely disentangle genetic factors causing obesity. The pig is a relevant model for studying human obesity and obesity-related (OOR) traits. Using founder breeds divergent with respect to obesity traits we have created an F2 pig resource population (454 pigs), which has been intensively phenotyped for 36 OOR traits. The main rationale for our study is to characterize the genetic architecture of OOR traits in the F2 pig design, by estimating heritabilities, genetic, and phenotypic correlations using mixed- and multi-trait BLUP animal models. Our analyses revealed high coefficients of variation (15-42%) and moderate to high heritabilities (0.22-0.81) in fatness traits, showing large phenotypic and genetic variation in the F2 population, respectively. This fulfills the purpose of creating a resource population divergent for OOR traits. Strong genetic correlations were found between weight and lean mass at dual-energy x-ray absorptiometry scanning (0.56-0.97). Weight and conformation also showed strong genetic correlations with slaughter traits (e.g., r g between abdominal circumference and leaf fat at slaughtering: 0.66). Genetic correlations between fat-related traits and the glucose level vary between 0.35 and 0.74 and show a strong correlation between adipose tissue and impaired glucose metabolism. Our power calculations showed a minimum of 80% power for QTL detection for all phenotypes. We revealed genetic correlations at population level, for the first time, for several difficult to measure and novel OOR traits and diseases. The results underpin the potential of the established F2 pig resource population for further genomic, systems genetics, and functional investigations to unravel the genetic background of OOR traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.