Evidence map›Paper›PMID 23514423›Full record

ReviewACS nano2013

Nanotools for neuroscience and brain activity mapping.

A Paul Alivisatos, Anne M Andrews, Edward S Boyden, Miyoung Chun, George M Church, Karl Deisseroth, John P Donoghue, Scott E Fraser, Jennifer Lippincott-Schwartz, Loren L Looger and 17 more

Abstract readReview
In one paragraph

Review in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed.

  1. Ethical Precision in Nanoscale Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
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  15. Article
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  18. Time for NanoNeuro.Nature methods · 2021
    Review
  19. Article
  20. Review

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

A Paul AlivisatosDepartment of Chemistry, University of California, Berkeley, California 94720, USA.
Anne M Andrews
Edward S Boyden
Miyoung Chun
George M Church
Karl Deisseroth
John P Donoghue
Scott E Fraser
Jennifer Lippincott-Schwartz
Loren L Looger
Sotiris Masmanidis
Paul L McEuen
Arto V Nurmikko
Hongkun Park
Darcy S Peterka
Clay Reid
Michael L Roukes
Axel Scherer
Mark Schnitzer
Terrence J Sejnowski
Kenneth L Shepard
Doris Tsao
Gina Turrigiano
Paul S Weiss
Chris Xu
Rafael Yuste
Xiaowei Zhuang

Funding

Organization and Dynamics of Endomembrane Pathways and OrganellesZIAHD001609 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BONIFACINO, JUAN · 2009 to 2019
$16.2M
Development of green fluorescent protein technologyZIAHD008850 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LIPPINCOTT-SCHWARTZ, JENNIFER · 2009 to 2016
$6.5M
High-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3M
Functional connectomics of the neocortical microcircuitDP1EY024503 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI YUSTE, RAFAEL · 2013 to 2017
$4.0M
Nanoscale Tools to Push Biomedical FrontiersDP1GM105376 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROUKES, MICHAEL L · 2012 to 2014
$2.4M
CRCNS: Gamma Rhythms and Cell AssembliesR01NS067199 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KOPELL, NANCY · 2009 to 2013
$1.7M
Howard Hughes Medical InstituteNEI NIH HHS DP1 EY024503NEI NIH HHS R01 EY023173NIGMS NIH HHS DP1 GM105376NINDS NIH HHS R01 NS067199
6 · The paper itself

Abstract

Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We attribute this disparity, in part, to limitations in current methodologies. Traditional neurophysiological approaches record the activities of one neuron or a few neurons at a time. Neurochemical approaches focus on single neurotransmitters. Yet, there is an increasing realization that neural circuits operate at emergent levels, where the interactions between hundreds or thousands of neurons, utilizing multiple chemical transmitters, generate functional states. Brains function at the nanoscale, so tools to study brains must ultimately operate at this scale, as well. Nanoscience and nanotechnology are poised to provide a rich toolkit of novel methods to explore brain function by enabling simultaneous measurement and manipulation of activity of thousands or even millions of neurons. We and others refer to this goal as the Brain Activity Mapping Project. In this Nano Focus, we discuss how recent developments in nanoscale analysis tools and in the design and synthesis of nanomaterials have generated optical, electrical, and chemical methods that can readily be adapted for use in neuroscience. These approaches represent exciting areas of technical development and research. Moreover, unique opportunities exist for nanoscientists, nanotechnologists, and other physical scientists and engineers to contribute to tackling the challenging problems involved in understanding the fundamentals of brain function.

Indexed as

AnimalsBrain MappingHumansModels, NeurologicalNanomedicineNanoparticlesNanotechnologyNervous System Physiological Phenomena

Identifiers

PMID23514423
PMCPMC3665747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.