ReviewCritical care (London, England)2013
Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside.
Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis.PloS one · 2015Trial
- Development and Validation of a Nomogram for Predicting Acute Skin Failure in Critically Ill Patients: A Prospective Study.Risk management and healthcare policy · 2026Article
- Predictive Value of SYN-1 Levels for Mortality in Sepsis Patients in the Emergency Department.Journal of inflammation research · 2024Article
- Microcirculation-guided resuscitation in sepsis: the next frontier?Frontiers in medicine · 2023Review
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- PulseCam: a camera-based, motion-robust and highly sensitive blood perfusion imaging modality.Scientific reports · 2020Article
- Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities.Frontiers in pediatrics · 2019Review
- An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality.Scientific reports · 2018Article
- Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine.Intensive care medicine · 2018Article
- Impact of microcirculatory video quality on the evaluation of sublingual microcirculation in critically ill patients.Journal of clinical monitoring and computing · 2017Article
- Systems Medicine-Complexity Within, Simplicity Without.Journal of healthcare informatics research · 2017Article
- Fluid responsiveness in critically ill patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature.Critical care (London, England) · 2015Review
- Dexamethasone Suppressed LPS-Induced Matrix Metalloproteinase and Its Effect on Endothelial Glycocalyx Shedding.Mediators of inflammation · 2015Article
- Clinical monitoring of peripheral perfusion: there is more to learn.Critical care (London, England) · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current hemodynamic monitoring of critically ill patients is mainly focused on monitoring of pressure-derived hemodynamic variables related to systemic circulation. Increasingly, oxygen transport pathways and indicators of the presence of tissue dysoxia are now being considered. In addition to the microcirculatory parameters related to oxygen transport to the tissues, it is becoming increasingly clear that it is also important to gather information regarding the functional activity of cellular and even subcellular structures to gain an integrative evaluation of the severity of disease and the response to therapy. Crucial to these developments is the need to provide continuous measurements of the physiological and pathophysiological state of the patient, in contrast to the intermittent sampling of biomarkers. As technological research and clinical investigations into the monitoring of critically ill patients have progressed, an increasing amount of information is being made available to the clinician at the bedside. This complexity of information requires integration of the variables being monitored, which requires mathematical models based on physiology to reduce the complexity of the information and provide the clinician with a road map to guide therapy and assess the course of recovery. In this paper, we review the state of the art of these developments and speculate on the future, in which we predict a physiological monitoring environment that is able to integrate systemic hemodynamic and oxygen-derived variables with variables that assess the peripheral circulation and microcirculation, extending this real-time monitoring to the functional activity of cells and their constituents. Such a monitoring environment will ideally relate these variables to the functional state of various organ systems because organ function represents the true endpoint for therapeutic support of the critically ill patient.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.