ArticleJournal of ophthalmic inflammation and infection2013
The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances.
Article in Journal of ophthalmic inflammation and infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Culture-proven endogenous endophthalmitis: ocular and systemic clinical features and outcomes.Journal of ophthalmic inflammation and infection · 2026Article
- Critical Care Management Considerations inCase reports in critical care · 2026Article
- Article
- Article
- SiderophoreBiochemistry and biophysics reports · 2022Article
- The making of hypervirulent Klebsiella pneumoniae.Journal of clinical laboratory analysis · 2022Review
- Severe Retinal Necrosis Due to Klebsiella pneumoniae After Acute Prostatitis.The American journal of case reports · 2022Article
- Endophthalmitis diagnosis supported by bedside ultrasound.Journal of the American College of Emergency Physicians open · 2022Article
- Clinical characteristics of endogenous Klebsiella pneumoniae endophthalmitis: a 13-year experience.International ophthalmology · 2022Article
- Characteristics of Computed Tomography for Identifying Patients at High Risk of Endogenous Endophthalmitis Due toJournal of clinical medicine · 2022Article
- Endogenous Endophthalmitis-The Clinical Significance of the Primary Source of Infection.Journal of clinical medicine · 2022Review
- Clinical and genomic characterization of hypervirulentFrontiers in microbiology · 2022Article
- HypervirulentLife (Basel, Switzerland) · 2021Review
- Endogenous Endophthalmitis Caused by ST66-K2 Hypervirulent Klebsiella pneumoniae, United States.Emerging infectious diseases · 2021Article
- Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess.BMC infectious diseases · 2020Article
- The cereus matter of Bacillus endophthalmitis.Experimental eye research · 2020Review
- Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives.Journal of internal medicine · 2020Review
- Prognostic Factors and Visual Outcomes of Pyogenic Liver Abscess-Related Endogenous Klebsiella pneumoniae Endophthalmitis: A 20-year retrospective review.Scientific reports · 2019Article
- Klebsiella pneumoniae endogenous endophthalmitis presenting as orbital cellulitis.GMS ophthalmology cases · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous endophthalmitis (EE) is a rare but devastating infection that occurs secondary to seeding of the intraocular cavity from an extraocular focus. Recent reports suggest the increasing prevalence and incidence of Klebsiella pneumoniae as a causative organism in Asian countries. Analysis of the largest cohorts published to date suggests that K. pneumoniae endogenous endophthalmitis (KPEE) is 10 to 15 times more prevalent than other causes of EE. The incidence of KPEE among patients with systemic Klebsiella infection appears to be >100-fold more common than other causes of EE. The exact reason for these observations is not clear, but a number of studies now suggest that Klebsiella serotypes K1 and K2 have virulence factors that enhance their survival in diabetic patients and increase their pathogenicity. Here, we report two cases of KPEE in the USA. We also review the recent clinical and basic science literature on the prevalence, incidence, and pathophysiology of this emerging and devastating infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.