ArticleJournal of ophthalmic inflammation and infection2013
Novel multi-targeted polymerase chain reaction for diagnosis of presumed tubercular uveitis.
Article in Journal of ophthalmic inflammation and infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 107 citations in OpenAlex.
- Current perspective on infectious uveitis.Indian journal of ophthalmology · 2026Review
- Comparison of uveitis manifestations in patients with active systemic tuberculosis and those with positive interferon-gamma release assay without active disease.Eye (London, England) · 2025Article
- Detection of Mycobacterium tuberculosis DNA in intraocular fluid of 11 suspected tuberculous uveitis patients by multiplex PCR.BMC ophthalmology · 2025Article
- Epidemiology and Clinical Characteristics of Ocular Tuberculosis in the United States, 1993-2019.Open forum infectious diseases · 2024Article
- Clinical manifestation and long-term follow-up of presumed ocular tuberculosis in China.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Ocular manifestations and diagnosis of tuberculosis involving the uvea: a case series.Tropical diseases, travel medicine and vaccines · 2023Article
- Diagnosis of pulmonary sarcoidosis in tuberculosis endemic area-a narrative review.Journal of thoracic disease · 2023Review
- Association of Micronutrients with Tuberculosis Development in HIV Infected Patients.Indian journal of clinical biochemistry : IJCB · 2023Article
- Diagnosis and biomarkers for ocular tuberculosis: From the present into the future.Theranostics · 2023Review
- Progress in the diagnosis of ocular sarcoidosis.Indian journal of ophthalmology · 2022Review
- Classification Criteria for Tubercular Uveitis.American journal of ophthalmology · 2021Article
- Ocular tuberculosis: Where are we today?Indian journal of ophthalmology · 2020Review
- Program-wide review and follow-up of erythema Induratum of Bazin and tuberculosis-associated ocular inflammation management in a TB low-incidence setting: need for improved treatment candidate selection, therapy standardization, and care collaboration.BMC infectious diseases · 2019Article
- Early treatment of tuberculous uveitis improves visual outcome: a 10-year cohort study.Infection · 2018Article
- MTBDRplus for the rapid diagnosis of ocular tuberculosis and screening of drug resistance.Eye (London, England) · 2018Article
- Ocular mycobacteriosis-dual infection of M. tuberculosis complex with M. fortuitum and M. bovis.Journal of ophthalmic inflammation and infection · 2017Article
- Comparative Study of GeneXpert MTB/RIF Assay and Multiplex PCR Assay for Direct Detection of Mycobacterium tuberculosis in Suspected Pulmonary Tuberculosis Patients.Current microbiology · 2017Article
- Paradoxical worsening of a case of TB subretinal abscess with serpiginous-like choroiditis following the initiation of antitubercular therapy.Indian journal of ophthalmology · 2017Article
- An unusual presentation of intraocular tuberculosis in a monocular patient: clinicopathological correlation.Journal of ophthalmic inflammation and infection · 2016Article
- Vanishing retinal arterial aneurysms with anti-tubercular treatment in a patient presenting with idiopathic retinal vasculitis, aneurysms, and neuroretinitis.Journal of ophthalmic inflammation and infection · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to report the use of multi-targeted polymerase chain reaction (PCR) in the diagnosis of presumed tubercular uveitis. Multi-targeted PCR using three targets specific for Mycobacterium tuberculosis, i.e., IS6110, MPB64, and protein b, was performed on intraocular fluid samples of 25 subjects. Nine had presumed tubercular uveitis, six had intraocular inflammation secondary to a nontubercular etiology (disease controls), and ten had no evidence of intraocular inflammation (normal controls). As described previously, response to antitubercular therapy was considered as the gold standard.
resultsMulti-targeted PCR was positive in seven out of nine patients with presumed tubercular uveitis and negative in all normal and disease controls. The sensitivity and specificity were 77.77% and 100%, respectively. For the diagnosis of presumed tubercular uveitis, multi-targeted PCR had a positive predictive value of 100% and a negative predictive value of 88.88%.
conclusionMulti-targeted PCR can be a valuable tool for diagnosing presumed tubercular uveitis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.