ArticleACS combinatorial science2013
Solution-phase parallel synthesis of a multisubstituted cyclic imidate library.
Article in ACS combinatorial science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Choline Chloride/Urea - Promoted Iodocyclization of 3-Alkynylthiophene-2-carboxamides: A Green Synthesis of 4-Iodo-7H-thieno[2,3-c]pyran-7-imines and Their Coupling Reactions in Deep Eutectic Solvents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
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5 authors.
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Abstract
The solution-phase parallel synthesis of a diverse 71-member library of multisubstituted cyclic imidates is described. The key intermediates, 3-iodomethylene-containing cyclic imidates, are readily prepared in good to excellent yields by the palladium/copper-catalyzed cross-coupling of various o-iodobenzamides and terminal alkynes, followed by electrophilic cyclization with I2. These cyclic imidates were further functionalized by palladium-catalyzed Suzuki-Miyaura, Sonogashira, carbonylative amidation, and Heck chemistry using sublibraries of commercially available building blocks.
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