Evidence map›Paper›PMID 23513177›Full record

ArticleF1000prime reports2013

Longevity and aging.

Matt Kaeberlein

Abstract read
In one paragraph

Article in F1000prime reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Trial
  2. Article
  3. Article
  4. Article
  5. Accelerated Epigenetic Aging and Prospective Morbidity and Mortality Among U.S. Veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  6. Article
  7. Accelerated biological aging and midlife frailty among U.S. military veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Observational
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. C22 disrupts embryogenesis and extendsFrontiers in physiology · 2023
    Article
  18. Life-Course Persistent Antisocial Behavior and Accelerated Biological Aging in a Longitudinal Birth Cohort.International journal of environmental research and public health · 2022
    Article
  19. Article
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Matt KaeberleinDepartment of Pathology, University of Washington Seattle, WA 98195 USA ; Institute of Aging Research, Guangdong Medical College Dongguan 523808 China.

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Su-In Lee · 1995 to 2026
$27.1M
Mechanisms of Life Span Extension By Dietary DeprivationR01AG031108 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VAN GILST, MARC R · 2008 to 2019
$3.2M
Mechanism of lifespan and healthspan regulation by the hypoxic response transcripR01AG038518 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT · 2011 to 2015
$1.5M
Endocrine Regulation of Survival Responses in C. elegansR01AG033598 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT · 2010 to 2014
$1.5M
Defining the Mechanisms of genotype-dependent responses to caloric restrictionR01AG039390 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT · 2011 to 2015
$1.5M
NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG031108NIA NIH HHS R01 AG033598NIA NIH HHS R01 AG038518NIA NIH HHS R01 AG039390
6 · The paper itself

Abstract

Research into the biology of aging seeks to understand the basic mechanisms of aging, with the goal of extending the period of life spent free from chronic disease and disability. Aging results from molecular processes that are modulated by genetic and environmental parameters. At least some of these mechanisms of aging are broadly shared across eukaryotic species from yeast to mice, and likely humans, as well. Recent breakthroughs in aging-related research have identified conserved longevity factors, such as components of the insulin-like signaling pathway and the mechanistic target of rapamycin, and have suggested potential paths toward developing the first interventions to slow aging in humans.

Identifiers

PMID23513177
PMCPMC3590784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.