Evidence map›Paper›PMID 23513068›Full record

Trial reportCirculation2013

Perioperative dexmedetomidine improves outcomes of cardiac surgery.

Fuhai Ji, Zhongmin Li, Hung Nguyen, Nilas Young, Pengcai Shi, Neal Fleming, Hong Liu

4 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 121 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 11 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01683448 completednot on this map

The Effect of Perioperative Medications on the Outcomes of Patients Undergoing Cardiac Surgery

TypeobservationalSponsorUniversity of California, DavisRan2010 to 2015Enrolled1ConditionsCardiac Diseases
NCT03624595 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial

TypeinterventionalSponsorDong-Xin WangRan2019 to 2025Enrolled504ConditionsCardiac Surgery, Cardiopulmonary Bypass, Dexmedetomidine, DeliriumArmsDexmedetomidine, Placebo
NCT04694105 nacompletednot on this mapstarted 2018, after this paper: background citation

Peri-neural Dexmedetomidine Versus Dexamethasone as an Adjuvant to Bupivacaine Single Injection in Ultrasoundguided Supraclavicular Brachial Plexus Block for Arteriovenous Fistula: A Randomized Controlled Study

TypeinterventionalSponsorCairo UniversityRan2018 to 2020Enrolled42ConditionsBrachial Plexus BlockArmsDexmedetomidine injection, Dexamethasone, saline
NCT04912518 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction: a Double-Blind, Multicenter, Randomized, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorHarbin Medical UniversityRan2021 to 2025Enrolled250ConditionsST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, CardioprotectionArmsDexmedetomidine (DEX), Placebo (Saline)
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 11 syntheses or guidelines pooled it, 307 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fuhai JiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhongmin Li
Hung Nguyen
Nilas Young
Pengcai Shi
Neal Fleming
Hong Liu
First Affiliated Hospital of Soochow University · CNSoochow University · CN

Funding

UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
NCATS NIH HHS UL1 TR000002
6 · The paper itself

Abstract

backgroundCardiac surgery is associated with a high risk of cardiovascular and other complications that translate into increased mortality and healthcare costs. This retrospective study was designed to determine whether the perioperative use of dexmedetomidine could reduce the incidence of complications and mortality after cardiac surgery. METHODS AND

resultsA total of 1134 patients who underwent coronary artery bypass surgery and coronary artery bypass surgery plus valvular or other procedures were included. Of them, 568 received intravenous dexmedetomidine infusion and 566 did not. Data were adjusted with propensity scores, and multivariate logistic regression was used. The primary outcomes measured included mortality and postoperative major adverse cardiocerebral events (stroke, coma, perioperative myocardial infarction, heart block, or cardiac arrest). Secondary outcomes included renal failure, sepsis, delirium, postoperative ventilation hours, length of hospital stay, and 30-day readmission. Dexmedetomidine use significantly reduced postoperative in-hospital (1.23% versus 4.59%; adjusted odds ratio, 0.34; 95% confidence interval, 0.192-0.614; P<0.0001), 30-day (1.76% versus 5.12%; adjusted odds ratio, 0.39; 95% confidence interval, 0.226-0.655; P<0.0001), and 1-year (3.17% versus 7.95%; adjusted odds ratio, 0.47; 95% confidence interval, 0.312-0.701; P=0.0002) mortality. Perioperative dexmedetomidine therapy also reduced the risk of overall complications (47.18% versus 54.06%; adjusted odds ratio, 0.80; 95% confidence interval, 0.68-0.96; P=0.0136) and delirium (5.46% versus 7.42%; adjusted odds ratio, 0.53; 95% confidence interval, 0.37-0.75; P=0.0030).

conclusionPerioperative dexmedetomidine use was associated with a decrease in postoperative mortality up to 1 year and decreased incidence of postoperative complications and delirium in patients undergoing cardiac surgery. CLINICAL

trial registrationURL: www.clinicaltrials.gov. Unique identifier: NCT01683448.

Indexed as

Cardiac Surgical ProceduresAcute Kidney InjuryAdrenergic alpha-2 Receptor AgonistsAgedCatecholaminesDeliriumDexmedetomidineFemaleHeart DiseasesHospital MortalityHospital RecordsHumansHypnotics and SedativesLength of StayMaleMiddle AgedAdrenergic alpha-2 Receptor AgonistsCatecholaminesDexmedetomidineHypnotics and Sedatives

Identifiers

PMID23513068
PMCPMC3979354
OpenAlexW1999285830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.