ReviewSchizophrenia bulletin2013
Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?
Review in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.Neuroscience and biobehavioral reviews · 2022Pooled it
- Weighing the evidence for harm from long-term treatment with antipsychotic medications: A systematic review.The American journal of orthopsychiatry · 2016Pooled it
- Pooled it
- Psychoeducation Improves Compliance and Outcome in Schizophrenia Without an Increase of Adverse Side Effects: A 7-Year Follow-up of the Munich PIP-Study.Schizophrenia bulletin · 2016Trial
- [Reduction and discontinuation of antipsychotic drugs in outpatient practice: perspectives of psychiatrists].Der Nervenarzt · 2026Article
- Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity.Molecular psychiatry · 2026Article
- Without Informed Consent: The Global Export of a Failed Paradigm of Care.Health and human rights · 2025Article
- Medications for psychosis in people with schizophrenia: what happens if you take them and what happens if you don't?CNS spectrums · 2025Review
- Roluperidone monotherapy, a treatment for negative symptoms in schizophrenia.The international journal of neuropsychopharmacology · 2025Article
- Targeted Treatment of Schizophrenia Symptoms as They Manifest, or Continuous Treatment to Reduce the Risk of Psychosis Recurrence.Schizophrenia bulletin · 2024Article
- Medication strategies in first episode psychosis patients: A survey among psychiatrists.Early intervention in psychiatry · 2022Article
- Moving Toward a Human Rights Approach to Mental Health.Community mental health journal · 2021Article
- The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies.Frontiers in psychiatry · 2021Review
- Are we getting any better at staying better? The long view on relapse and recovery in first episode nonaffective psychosis and schizophrenia.Therapeutic advances in psychopharmacology · 2019Review
- The debate regarding maintenance treatment with antipsychotic drugs in schizophrenia.Dialogues in clinical neuroscience · 2018Article
- Continue, adjust, or stop antipsychotic medication: developing and user testing an encounter decision aid for people with first-episode and long-term psychosis.BMC psychiatry · 2018Article
- 'The threads in his mind have torn': conceptualization and treatment of mental disorders by neo-prophetic Christian healers in Accra, Ghana.International journal of mental health systems · 2018Article
- Declining Clinical Course of Psychotic Disorders Over the Two Decades Following First Hospitalization: Evidence From the Suffolk County Mental Health Project.The American journal of psychiatry · 2017Article
- A 20-Year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia.Psychiatry research · 2017Article
- On discontinuing treatment in schizophrenia: a clinical conundrum.NPJ schizophrenia · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Antipsychotic medications are viewed as cornerstones for both the short-term and long-term treatment of schizophrenia. However, evidence on long-term (10 or more years) efficacy of antipsychotics is mixed. Double-blind discontinuation studies indicate significantly more relapses in unmedicated schizophrenia patients in the first 6-10 months, but also present some potentially paradoxical features. These issues are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.