ArticleObesity (Silver Spring, Md.)2014
Fat accumulation in the liver of obese rats is alleviated by soy protein isolate through β-catenin signaling.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- The Effect of Caffeine on Wnt/β-Catenine and P38 Mitogen-Activated Protein Kinases (MAPK) Signal Pathways and Some Biochemical Parameters on Cafeteria Diet in Rats.Food science & nutrition · 2025Article
- Hypolipidemic Effects of Soy Protein and Isoflavones in the Prevention of Non-Alcoholic Fatty Liver Disease- A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2022Review
- Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-Catenin Downregulation and AMPK Activation.Pharmaceutics · 2021Article
- β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet.European journal of histochemistry : EJH · 2020Article
- Relevance of VEGFA in rat livers subjected to partial hepatectomy under ischemia-reperfusion.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation.The Journal of physiology · 2018Article
- Short-Term Soy Protein Isolate Feeding Prevents Liver Steatosis and Reduces Serum ALT and AST Levels in Obese Female Zucker Rats.Biomedicines · 2018Article
- Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle.Journal of genetics · 2017Article
- Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats.The Journal of nutritional biochemistry · 2017Article
- Soy-based renoprotection.World journal of nephrology · 2016Review
- Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats.Genes & nutrition · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the effects of soy protein isolate (SPI) on Wnt/β-catenin signaling in the liver of obese rats, as well as the roles of this pathway in regulating the hepatic fat accumulation. DESIGN AND
methodsObese and lean Zucker rats were fed diets containing either casein or SPI as protein source for 17 weeks. Histology and biochemical analysis, real-time PCR, Western blot, immunostaining, short interfering RNA assay were performed for liver samples.
resultsOur study showed that fat content was significantly lowered in the liver of SPI-fed obese rats, accompanied by a reduction in hepatocellular vacuolation, compared to the casein-fed control. β-Catenin protein level in the liver of obese rats was downregulated compared to the lean group, indicating that the obese genotype exhibits an overall reduction in Wnt signaling. Importantly the repression of β-catenin in the obese rats was alleviated by feeding the SPI diet. siRNA treatment in rat hepatoma cells confirmed that silencing of β-catenin exacerbated fatty acid-induced fat accumulation, which implicated an important function of Wnt/β-catenin signaling in hepatic fat metabolism.
conclusionSPI intake restored β-catenin signaling and alleviated hepatic fat accumulation and liver damage in the obese rats.
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Registered trials
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