Trial reportObesity (Silver Spring, Md.)2013
Lifestyle intervention and/or statins for the reduction of C-reactive protein in type 2 diabetes: from the look AHEAD study.
Trial report in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial.Cancer prevention research (Philadelphia, Pa.) · 2020Trial
- Effect of diet or diet plus physical activity versus usual care on inflammatory markers in patients with newly diagnosed type 2 diabetes: the Early ACTivity in Diabetes (ACTID) randomized, controlled trial.Journal of the American Heart Association · 2014Trial
- Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China.Frontiers in public health · 2025Article
- Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus.World journal of experimental medicine · 2023Review
- The role of Wnt pathway in obesity induced inflammation and diabetes: a review.Journal of diabetes and metabolic disorders · 2021Review
- Obesity and Cardiovascular Disease: The Emerging Role of Inflammation.Frontiers in cardiovascular medicine · 2021Review
- Influence of the Mediterranean and Ketogenic Diets on Cognitive Status and Decline: A Narrative Review.Nutrients · 2020Review
- The Role of Lymphatic Vascular Function in Metabolic Disorders.Frontiers in physiology · 2020Review
- Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.International journal of physiology, pathophysiology and pharmacology · 2019Review
- Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk.The Journal of clinical investigation · 2017Review
- Prognostic Importance of C-Reactive Protein in High Cardiovascular Risk Patients With Type 2 Diabetes Mellitus: The Rio de Janeiro Type 2 Diabetes Cohort Study.Journal of the American Heart Association · 2016Observational
- Lipid-lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS).Journal of clinical periodontology · 2015Article
- Weight Loss and the Prevention and Treatment of Type 2 Diabetes Using Lifestyle Therapy, Pharmacotherapy, and Bariatric Surgery: Mechanisms of Action.Current obesity reports · 2015Review
- Inflammation, Oxidative Stress, and Antioxidants Contribute to Selected Sleep Quality and Cardiometabolic Health Relationships: A Cross-Sectional Study.Mediators of inflammation · 2015Article
- Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.Current atherosclerosis reports · 2014Review
- The Look AHEAD Trial: A Review and Discussion Of Its Outcomes.Current nutrition reports · 2014Article
- Look Action for Health in Diabetes trial: What we have learned in terms of real world practice and clinical trials.Journal of diabetes investigation · 2014Article
- Helminth infections, type-2 immune response, and metabolic syndrome.PLoS pathogens · 2014Review
- Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.American journal of human genetics · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
objectiveCardiovascular risk remains high despite statin use. Overweight/obese diabetic persons usually have normal/low LDL-cholesterol but high C-reactive protein (CRP) levels. We aimed to examine the effects of intensive lifestyle intervention for weight loss (ILI) on CRP levels in overweight/obese diabetic individuals by statin use. DESIGN AND
methodsLook AHEAD was a randomized trial in overweight/obese type 2 diabetic individuals testing whether ILI would reduce cardiovascular mortality, when compared to usual care. CRP changes in 1,431 participants with biomarker levels, who remained on or off statin treatment for 1 year, were evaluated.
resultsThe reduction in CRP levels with ILI at 1 year in men and women on statins was -44.9 and -42.3%, respectively, compared to -13.7 and -21.0% for those on statins and usual care (P < 0.0001). At 1 year, median CRP levels were: 1.8 mg L(-1) in participants randomized to ILI on statin therapy; 2.6 mg L(-1) for those on statins randomized to usual care and 2.9 mg L(-1) for participants not on statins but randomized to ILI. Weight loss was associated with 1-year CRP reduction (P < 0.0001) in statin and nonstatin users.
conclusionsOur findings suggest that in overweight/obese diabetic persons, ILI and statin therapy may have substantial additive anti-inflammatory benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.