ArticleThe Plant cell2013
14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 119 citations in OpenAlex.
- MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago - Sinorhizobium symbiosis.The New phytologist · 2026Article
- 14-3-3 proteins: Central hubs in plant development and stress adaptation.Journal of integrative plant biology · 2026Review
- 14-3-3 λ suppresses ethylene-mediated root growth inhibition through EIN3/EIL1 in Aratbidopsis.Plant physiology · 2026Article
- TaGF14g, a wheat 14-3-3 protein, acts as a positive regulator of drought and salt tolerance.Plant cell reports · 2025Article
- Function and defense mechanisms of wheat 14-3-3 protein TaGF14a in stripe rust resistance.BMC biology · 2025Article
- The 14-3-3 Protein SlTFT1 Accelerates Tomato Fruit Ripening by Binding and Stabilising YFT1 in the Ethylene Signalling Pathway.Plant biotechnology journal · 2025Article
- Article
- StACS3-mediated drought stress adaptation in potato involves interactions with StPP2C2 and St14-3-3 proteins.Frontiers in plant science · 2025Article
- Rhizobia and non-rhizobial nodule bacteria with ACC deaminase increase both nodulation and stress resistance.Frontiers in microbiology · 2025Review
- Phosphorylation of the transcription factor OsNAC29 by OsMAPK3 activates diterpenoid genes to promote rice immunity.The Plant cell · 2024Article
- The Ethylene Biosynthetic Enzymes, 1-Aminocyclopropane-1-Carboxylate (ACC) Synthase (ACS) and ACC Oxidase (ACO): The Less Explored Players in Abiotic Stress Tolerance.Biomolecules · 2024Review
- Genome-Wide Identification and Expression Analysis of 1-Aminocyclopropane-1-Carboxylate Synthase (Plants (Basel, Switzerland) · 2023Article
- Time-Dependent Proteomic Signatures Associated with Embryogenic Callus Induction inPlants (Basel, Switzerland) · 2023Article
- Review
- Transcriptional Profiling Reveals the Wheat Defences against Fusarium Head Blight Disease Regulated by a NAC Transcription Factor.Plants (Basel, Switzerland) · 2023Article
- Genome-Wide Identification and Expression Analysis of the 14-3-3 (TFT) Gene Family in Tomato, and the Role ofPlants (Basel, Switzerland) · 2022Article
- Genome-wide identification and gene expression analysis of the 14-3-3 gene family in potato (Solanum tuberosum L.).BMC genomics · 2022Article
- Potential Roles of 1-Aminocyclopropane-1-carboxylic Acid Synthase Genes in the Response ofPlants (Basel, Switzerland) · 2022Article
- Crosstalk between theInternational journal of molecular sciences · 2022Article
- SnRK2 subfamily I protein kinases regulate ethylene biosynthesis by phosphorylating HB transcription factors to induce ACO1 expression in apple.The New phytologist · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
14-3-3 proteins are a family of conserved phospho-specific binding proteins involved in diverse physiological processes. Plants have large 14-3-3 gene families, and many binding partners have been identified, though relatively few functions have been defined. Here, we demonstrate that 14-3-3 proteins interact with multiple 1-aminocyclopropane-1-carboxylate synthase (ACS) isoforms in Arabidopsis thaliana. ACS catalyzes the generally rate-limiting step in the biosynthesis of the phytohormone ethylene. This interaction increases the stability of the ACS proteins. 14-3-3s also interact with the ETHYLENE-OVERPRODUCER1 (ETO1)/ETO1-LIKE (EOLs), a group of three functionally redundant proteins that are components of a CULLIN-3 E3 ubiquitin ligase that target a subset of the ACS proteins for rapid degradation by the 26S proteasome. In contrast with ACS, the interaction with 14-3-3 destabilizes the ETO1/EOLs. The level of the ETO1/EOLs in vivo plays a role in mediating ACS protein turnover, with increased levels leading to a decrease in ACS protein levels. These studies demonstrate that regulation of ethylene biosynthesis occurs by a mechanism in which 14-3-3 proteins act through a direct interaction and stabilization of ACS and through decreasing the abundance of the ubiquitin ligases that target a subset of ACS proteins for degradation.
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