Evidence map›Paper›PMID 23512759›Full record

Trial reportBMJ (Clinical research ed.)2013

One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial.

Dale M Needham, Victor D Dinglas, O Joseph Bienvenu, Elizabeth Colantuoni, Amy W Wozniak, Todd W Rice, Ramona O Hopkins, NIH NHLBI ARDS Network

2 registry-linked trialsOpen access · hybridAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 121 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 9 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03025373 completednot on this mapstarted 2017, after this paper: background citation

Virtual Reality Stimulation to Enhance Cognitive Function of Intensive Care Unit Patients

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2017 to 2019Enrolled67ConditionsCognitive Impairment, Mild, Quality of LifeArmsVisuo-acoustic stimulation
NCT04242966 phase3withdrawnnot on this mapstarted 2020, after this paper: background citation

The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-based Randomized Trial: The EFFORT Ultrasound a Sub-study

TypeinterventionalSponsorClinical Evaluation Research Unit at Kingston General HospitalRan2020 to 2022Enrolled0ConditionsCritical Illness, MalnutritionArmsUsual Care, Higher Protein/Amino Acid Group, Ultrasound measure
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 9 syntheses or guidelines pooled it, 279 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review.American journal of respiratory and critical care medicine · 2020
    Pooled it
  4. [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020
    Guideline
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Guideline
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dale M NeedhamOutcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, MD 21205, USA. dale.needham@jhmi.edu
Victor D Dinglas
O Joseph Bienvenu
Elizabeth Colantuoni
Amy W Wozniak
Todd W Rice
Ramona O Hopkins
NIH NHLBI ARDS Network
Johns Hopkins University · USBrigham Young University · USVanderbilt University · US

Funding

Treatment of Acute Lung Injury and Acute Respiratory Distress SyndromeN01HR56170 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BROWER, ROY G. · 2007 to 2014
$2.6M
Patient Outcomes 6 and 12 Months After ALTA, OMEGA and EDEN ARDS Network TrialsR01HL091760 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HOPKINS, RAMONA O, NEEDHAM, DALE MURRAY · 2008 to 2011
$2.0M
Citrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisR34HL105869 · NHLBI · VANDERBILT UNIVERSITY · PI RICE, TODD W · 2012 to 2014
$686k
NHLBI NIH HHS 3R01HL091760-02S1NHLBI NIH HHS N01HR56170NHLBI NIH HHS R01HL091760NHLBI NIH HHS R34 HL105869PHS HHS HHSN268200536165CPHS HHS HHSN268200536176CPHS HHS HHSN268200536179C
6 · The paper itself

Abstract

objectiveTo evaluate the effect of initial low energy permissive underfeeding ("trophic feeding") versus full energy enteral feeding ("full feeding") on physical function and secondary outcomes in patients with acute lung injury.

designProspective longitudinal follow-up evaluation of the NHLBI ARDS Clinical Trials Network's EDEN trial

setting41hospitals in the United States.

participants525 patients with acute lung injury.

interventionsRandomised assignment to trophic or full feeding for up to six days; thereafter, all patients still receiving mechanical ventilation received full feeding. MEASUREMENTS: Blinded assessment of the age and sex adjusted physical function domain of the SF-36 instrument at 12 months after acute lung injury. Secondary outcome measures included survival; physical, psychological, and cognitive functioning; quality of life; and employment status at six and 12 months.

resultsAfter acute lung injury, patients had substantial physical, psychological, and cognitive impairments, reduced quality of life, and impaired return to work. Initial trophic versus full feeding did not affect mean SF-36 physical function at 12 months (55 (SD 33) v 55 (31), P=0.54), survival to 12 months (65% v 63%, P=0.63), or nearly all of the secondary outcomes.

conclusionIn survivors of acute lung injury, there was no difference in physical function, survival, or multiple secondary outcomes at 6 and 12 month follow-up after initial trophic or full enteral feeding.

trial registrationNCT No 00719446.

Indexed as

Energy IntakeAcute Lung InjuryAdultAgedCritical IllnessEnteral NutritionFemaleFollow-Up StudiesHospital MortalityHumansLongitudinal StudiesMaleMiddle AgedNutritional RequirementsParenteral NutritionProspective Studies

Identifiers

PMID23512759
PMCPMC3601941
OpenAlexW1974798003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.