Trial reportObesity (Silver Spring, Md.)2013
A low-glycemic diet lifestyle intervention improves fat utilization during exercise in older obese humans.
Trial report in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Are Individuals With Type 2 Diabetes Metabolically Inflexible? A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2025Pooled it
- Nutrition and Exercise Interventions to Improve Body Composition for Persons with Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Low-Glycemic Index Diets as an Intervention in Metabolic Diseases: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Trial
- Exercise-induced improvements in glucose effectiveness are blunted by a high glycemic diet in adults with prediabetes.Acta diabetologica · 2019Trial
- Carbohydrate intake and glycemic index affect substrate oxidation during a controlled weight cycle in healthy men.European journal of clinical nutrition · 2014Trial
- Low glycaemic index or low glycaemic load diets for people with overweight or obesity.The Cochrane database of systematic reviews · 2023Review
- Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes.Medicine and science in sports and exercise · 2020Article
- Exercise training promotes a GDF15-associated reduction in fat mass in older adults with obesity.American journal of physiology. Endocrinology and metabolism · 2019Article
- The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out".JAMA internal medicine · 2018Review
- Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Targeting Postprandial Hyperglycemia With Physical Activity May Reduce Cardiovascular Disease Risk. But What Should We Do, and When Is the Right Time to Move?Frontiers in cardiovascular medicine · 2018Review
- Excessive Body Weight in Older Adults.Clinics in geriatric medicine · 2015Review
- Article
- Obesity and physical frailty in older adults: a scoping review of lifestyle intervention trials.Journal of the American Medical Directors Association · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo determine the influence of dietary glycemic index on exercise training-induced adaptations in substrate oxidation in obesity. DESIGN AND
methodsTwenty older, obese individuals undertook 3 months of fully supervised aerobic exercise and were randomized to low- (LoGIX) or high-glycemic (HiGIX) diets. Changes in indirect calorimetry (VO2 ; VCO2 ) were assessed at rest, during a hyperinsulinemic-euglycemic clamp, and during submaximal exercise (walking: 65% VO2 max, 200 kcal energy expenditure). Intramyocellular lipid (IMCL) was measured by (1) H-magnetic resonance spectroscopy.
resultsWeight loss (-8.6 ± 1.1%) and improvements (P < 0.05) in VO2 max, glycemic control, fasting lipemia, and metabolic flexibility were similar for both LoGIX and HiGIX groups. During submaximal exercise, energy expenditure was higher following the intervention (P < 0.01) in both groups. Respiratory exchange ratio during exercise was unchanged in the LoGIX group but increased in the HiGIX group (P < 0.05). However, fat oxidation during exercise expressed in relation to changes in body weight was increased in the LoGIX group (+10.6 ± 3.6%; P < 0.05). Fasting IMCL was unchanged, however, extramyocellular lipid was reduced (P < 0.05) after LoGIX.
conclusionsA LoGIX/exercise weight-loss intervention increased fat utilization during exercise independent of changes in energy expenditure. This highlights the potential therapeutic value of low-glycemic foods for reversing metabolic defects in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.