ArticleObesity (Silver Spring, Md.)2014
Serum hepcidin levels are associated with obesity but not liver disease.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- The convergent roles of metabolic dysfunction, alcohol, and iron in steatotic liver disease: a review.Bioscience reports · 2026Review
- Relationship of serum iron and thyroid hormone in obesity and after laparoscopic sleeve gastrectomy.BMC endocrine disorders · 2024Observational
- Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents.International journal of environmental research and public health · 2022Article
- The role of iron metabolism in chronic diseases related to obesity.Molecular medicine (Cambridge, Mass.) · 2022Review
- Effects of Moderate Consumption of Red Wine on Hepcidin Levels in Patients with Type 2 Diabetes Mellitus.Foods (Basel, Switzerland) · 2022Article
- Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Hepcidin Levels and Pathological Characteristics in Children with Fatty Liver Disease.Pediatric gastroenterology, hepatology & nutrition · 2021Article
- Serum Hepcidin-25 and Risk of Mortality in Patients on Peritoneal Dialysis.Frontiers in medicine · 2021Article
- Iron overload and Hepcidin overexpression could play a key role in COVID infection, and may explain vulnerability in elderly, diabetics, and obese patients.Acta bio-medica : Atenei Parmensis · 2020Article
- Dysregulated Iron Metabolism-Associated Dietary Pattern Predicts an Altered Body Composition and Metabolic Syndrome.Nutrients · 2019Article
- Iron and liver fibrosis: Mechanistic and clinical aspects.World journal of gastroenterology · 2019Review
- Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease.BMC gastroenterology · 2018Article
- Low hepcidin in liver fibrosis and cirrhosis; a tale of progressive disorder and a case for a new biochemical marker.Molecular medicine (Cambridge, Mass.) · 2018Review
- Cyp1b1 deletion and retinol deficiency coordinately suppress mouse liver lipogenic genes and hepcidin expression during post-natal development.Molecular and cellular endocrinology · 2017Article
- High level of hemoglobin, white blood cells and obesity among Sudanese women in early pregnancy: a cross-sectional study.Future science OA · 2017Article
- Article
- Anemia after Roux-en-Y gastric bypass. How feasible to eliminate the risk by proper supplementation?Obesity surgery · 2015Article
- Serum hepcidin levels and iron metabolism in obese children with and without fatty liver: case-control study.European journal of pediatrics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveHepcidin is regulated by anemia and inflammation. It is primarily expressed in the liver but studies have reported its expression in adipose tissue. The relationship between BMI and serum hepcidin and the relationship between liver histology and serum hepcidin in the morbidly obese was investigated.
methodsSerum and liver tissue from patients undergoing bariatric surgery (bariatric cohort, n = 105) and serum from healthy blood donors (n = 60) were used to conduct this study. Serum hepcidin was measured using sandwich ELISA, highly specific for hepcidin-25. Serum ferritin, IL-6, IL-1β and liver function biochemistries were also measured.
resultsAfter controlling for covariates, BMI ≥ 35 kg/m(2) was significantly associated with higher serum hepcidin level compared to individuals with lower BMI groups (17.7 ± 11.5 vs. 3.3 ± 4.7 ng/ml, P = 0.002). The presence of NAFLD was not associated with higher serum levels of hepcidin (multivariate P = 0.37). There was no association between serum hepcidin levels and liver histology (presence of steatohepatitis, advanced fibrosis, or NAFLD activity score) in the bariatric cohort.
conclusionsObesity, but not the presence of NAFLD was associated with serum hepcidin levels. There was no association between serum hepcidin and liver histology in the morbidly obese undergoing bariatric surgery.
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