ArticleDigestive diseases and sciences2013
Pain and opioid use in chronic liver disease.
Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis.Palliative medicine · 2019Pooled it
- Impact of Medication for Opioid Use Disorder on Patient Directed Discharge Among Patients with Opioid Use Disorder.Journal of general internal medicine · 2026Article
- A tailored pain self-management intervention for patients with cirrhosis is acceptable and improves pain control.Hepatology communications · 2026Article
- Navigating Chronic Pain in Patients with Cirrhosis: Unique Analgesic Considerations and Non-Pharmacologic Options.Current hepatology reports · 2026Review
- Substance Use-Related Admissions in Liver Transplant Recipients: A National Inpatient Sample Analysis.Journal of transplantation · 2026Article
- Cannabis and liver transplant in the era of legalization: Effects of pretransplant cannabis use on postoperative opioid use and transplant outcomes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025Article
- Multidimensional experience of pain in adults with cirrhosis: A qualitative descriptive study.Canadian journal of pain = Revue canadienne de la douleur · 2025Article
- Multidimensional Experience of Pain in Adults With Cirrhosis: A Cross-sectional Survey Study.Gastro hep advances · 2025Article
- Non-pharmacological Interventions for Muscle Cramps and Pain in Patients With Cirrhosis: A Systematic Review.Cureus · 2024Review
- Using Intervention Mapping to Develop a Novel Pain Self-Management Intervention for People with Cirrhosis.Digestive diseases and sciences · 2022Article
- AASLD Practice Guidance: Palliative care and symptom-based management in decompensated cirrhosis.Hepatology (Baltimore, Md.) · 2022Article
- Long-Term Opioid Use Among Veterans with Cirrhosis: High-Dose Prescriptions in an Exceedingly High-Risk Population.Journal of general internal medicine · 2022Article
- Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation.Iranian journal of medical sciences · 2022Article
- Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.Hepatology communications · 2022Article
- Opioid Use Is More Common in Nonalcoholic Fatty Liver Disease Patients with Cirrhosis, Higher BMI, and Psychiatric Disease.Digestive diseases (Basel, Switzerland) · 2021Observational
- Characteristics of opioid prescribing to outpatients with chronic liver diseases: A call for action.PloS one · 2021Article
- Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway.Public health in practice (Oxford, England) · 2020Article
- A scoping review to identify and map the multidimensional domains of pain in adults with advanced liver disease.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Health-related quality of life and patient-reported outcome measures in NASH-related cirrhosis.JHEP reports : innovation in hepatology · 2020Article
- Opioid prescriptions are associated with hepatic encephalopathy in a national cohort of patients with compensated cirrhosis.Alimentary pharmacology & therapeutics · 2020Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPain is common in patients with liver disease, difficult to treat, and poorly understood.
aimsThe aim of this study was to determine factors associated with pain and prescription opioid use in a large cohort of patients with confirmed chronic liver disease.
methodsThis was a retrospective cohort study of consecutive patients with chronic liver disease visiting a tertiary-care hepatology clinic. Pain was determined by self-report and rated numerically from 0 to 10. Symptoms of mood and sleep disorders and emotional distress were based on a symptom checklist. Etiology and stage of liver disease and use of prescribed opioids were abstracted from the electronic medical record. Logistic regression was used to establish factors associated with pain and prescription opioid use.
resultsAmong 1,286 patients with chronic liver disease, 34 % had pain and 25 % used opioids. The strongest predictor of pain in multivariate modeling was emotional distress (OR 3.66, 95 % CI 2.40-5.64), followed by non-white race (OR 1.87, 95 % CI 1.24-2.79), mood symptoms (OR 1.47, 95 % CI 1.04-2.07), sleep disturbance/fatigue (OR 1.70, 95 % CI 1.24-2.32), and advanced liver disease (Child class B: OR 1.73, 95 % CI 1.15-2.60; Child class C: OR 2.78, 95 % CI 1.49-5.24) compared to no cirrhosis. Emotional distress, mood-related symptoms, and advanced liver disease were also significant predictors of prescription opioid use, as were age, nicotine use, and etiology of liver disease.
conclusionsThis large cohort study demonstrates the high prevalence of pain and opioid use in chronic liver disease. While disease variables contribute to pain, psychological symptoms were most strongly associated with pain and opioid use, providing rationale and target for therapeutic interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.