ArticleCellular and molecular neurobiology2013
Telomerase activity in human brain tumors: astrocytoma and meningioma.
Article in Cellular and molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- The causal relationship between genetically determined telomere length and meningiomas risk.Frontiers in neurology · 2023Article
- TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma.Neuro-oncology · 2018Article
- Exploration of Involved Key Genes and Signaling Diversity in Brain Tumors.Cellular and molecular neurobiology · 2018Review
- The Emerging Roles for Telomerase in the Central Nervous System.Frontiers in molecular neuroscience · 2018Review
- Comprehensive analysis of Iranian reports of pediatric central nervous system tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Assessment Effects of Resveratrol on Human Telomerase Reverse Transcriptase Messenger Ribonucleic Acid Transcript in Human Glioblastoma.Advanced biomedical research · 2017Article
- Vaccination strategies for neuro-oncology.Neuro-oncology · 2015Review
- Brain tumors: Special characters for research and banking.Advanced biomedical research · 2015Review
- Oncolytic adenoviruses: A thorny path to glioma cure.Genes & diseases · 2014Article
- High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression.Brain pathology (Zurich, Switzerland) · 2014Article
- The evolving role of radiosurgery in the management of radiation-induced meningiomas: a review of current advances and future directions.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatic cells do not have telomerase activity but immortalized cell lines and more than 85 % of the cancer cells show telomerase activation to prevent the telomere from progressive shortening. The activation of this enzyme has been found in a variety of human tumors and tumor-derived cell lines, but only few studies on telomerase activity in human brain tumors have been reported. Here, we evaluated telomerase activity in different grades of human astrocytoma and meningioma brain tumors. In this study, assay for telomerase activity performed on 50 eligible cases consisted of 26 meningioma, 24 astrocytoma according to the standard protocols. In the brain tissues, telomerase activity was positive in 39 (65 %) of 50 patients. One sample t test showed that the telomerase activity in meningioma and astrocytoma tumors was significantly positive entirely (P < 0.001). Also, grade I of meningioma and low grades of astrocytoma (grades I and II) significantly showed telomerase activity. According to our results, we suggest that activation of telomerase is an event that starts mostly at low grades of brain including meningioma and astrocytoma tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.