ReviewEndocrine pathology2013
Double, synchronous pituitary adenomas causing acromegaly and Cushing's disease. A case report and review of literature.
Review in Endocrine pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Double pituitary adenomas: report of two cases and systematic review of the literature.Frontiers in endocrinology · 2024Pooled it
- Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature.Pituitary · 2017Pooled it
- Clinical management challenges of Cushing's disease associated with double pituitary adenomas: four cases and literature review.Endocrine · 2026Review
- Double PitNETs: A Case Report and Literature Review.Cancers · 2025Review
- [Clinical case of plurihormonal pituitary adenoma (STH/ACTH/TSH/FSH/LH-secreting), diagnostic pitfalls].Problemy endokrinologii · 2024Article
- Plurihormonal Pituitary Neuroendocrine Tumors: Clinical Relevance of Immunohistochemical Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Double pituitary neuroendocrine tumors in a patient with normal growth hormone level acromegaly: A case report and review of the literature.Surgical neurology international · 2023Article
- Article
- Double pituitary adenomas in a large surgical series.Pituitary · 2019Article
- Double separate versus contiguous pituitary adenomas: MRI features and endocrinological follow up.Pituitary · 2016Article
- Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature.Oncology letters · 2016Article
- Multiple Pituitary Adenomas: A Systematic Review.Frontiers in endocrinology · 2016Review
- Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly.Scientific reports · 2015Article
- Comment on: double, synchronous pituitary adenomas causing acromegaly and Cushing's disease. A case report and review of literature. Endocr Pathol 2013;24:92-99.Endocrine pathology · 2014Article
- TWO SYNCHRONOUS PITUITARY ADENOMAS CAUSING CUSHING DISEASE AND ACROMEGALY.AACE clinical case reportsArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Double pituitary adenomas are very rare and present up to 1 % of pituitary adenomas in unselected autopsy series and up to 2 % in large surgical series. We report a case of a 47-year-old man presented slight clinical features of acromegaly with 2 years duration. Endocrine evaluation confirmed active acromegaly and revealed adrenocorticotropin hormone-dependent hypercortisolemia. Preoperative magnetic resonance imaging of the pituitary demonstrated clearly separated double microadenomas with different intensity. The patient underwent transsphenoidal surgery and both tumors were completely removed and were fixed separately. The histological and ultrastructural examination confirmed coincidence of the double, clearly separated pituitary adenomas in one gland. Postoperative function of the hypothalamo-hypophyseal axis was normalized. We conclude from this case and a literature review that double endocrinologically active pituitary adenomas leading to acromegaly and Cushing's disease may occur. Additionally, a review of the literature regarding multiple pituitary adenomas has also been performed.
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