Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
Laser speckle imaging allows real-time intraoperative blood flow assessment during neurosurgical procedures.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Bypass in neurosurgery-indications and techniques.Neurosurgical review · 2019Pooled it
- Assessment of tissue perfusion changes in port wine stains after vascular targeted photodynamic therapy: a short-term follow-up study.Lasers in medical science · 2014Trial
- In Vivo Monitoring of Pressure Ulcer Model Development and Recoverability Under Multimodal Parameters Within a Unified Field of View.Journal of biophotonics · 2026Article
- DASHING-LSCI: deep learning-based anatomical multiclass segmentation for human intraoperative neurosurgical guidance - laser speckle contrast imaging.Biomedical optics express · 2026Article
- Multimodal imaging and AI in brain tumor surgery: current tools and emerging integration.npj biomedical innovations · 2026Review
- Article
- Physiology, monitoring, and optimisation of perioperative tissue oxygenation: a narrative review.British journal of anaesthesia · 2026Review
- Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgery.Frontiers of optoelectronics · 2025Article
- Article
- Intraoperative evaluation of local cerebral hemodynamic change by laser speckle contrast imaging for predicting postoperative cerebral hyperperfusion during STA-MCA bypass in adult patients with moyamoya disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Laser speckle contrast imaging versus microvascular Doppler sonography in aneurysm surgery: A prospective study.World neurosurgery: X · 2024Article
- Review: Preclinical Models of Large-Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2024Review
- Intraoperative Neurophysiological Monitoring in Neurosurgery.Journal of clinical medicine · 2024Review
- Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging - a pilot study.Innovative surgical sciences · 2024Article
- A Brief Introduction to the Study of Cerebral Blood Flow Measurement in Traumatic Brain Injury Using Optical Imaging Approach.Korean journal of neurotrauma · 2024Article
- Cortical perfusion measurements with laser speckle contrast imaging during adenosine induced cardiac arrest for aneurysm clipping: a case report.Acta neurochirurgica · 2024Article
- Using Laser Speckle Contrast Imaging to Quantify Perfusion Quality in Kidney and Pancreas Grafts on Vascular Reperfusion: A Proof-of-Principle Study.Transplantation direct · 2023Article
- Laser speckle contrast analysis (LASCA): a new device in the diagnosis and monitoring of surgical treatment of hidradenitis suppurativa.Postepy dermatologii i alergologii · 2023Article
- Application of laser speckle flowgraphy to evaluate cerebral perfusion after carotid endarterectomy.Heliyon · 2023Article
- Continuous hemodynamics monitoring during arteriovenous malformation microsurgical resection with laser speckle contrast imaging: case report.Frontiers in surgery · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, there is no adequate technique for intraoperative monitoring of cerebral blood flow (CBF). To evaluate laser speckle imaging (LSI) for assessment of relative CBF, LSI was performed in 30 patients who underwent direct surgical revascularization for treatment of arteriosclerotic cerebrovascular disease (ACVD), Moyamoya disease (MMD), or giant aneurysms, and in 8 control patients who underwent intracranial surgery for reasons other than hemodynamic compromise. The applicability and sensitivity of LSI was investigated through baseline perfusion and CO2 reactivity testing. The dynamics of LSI were assessed during bypass test occlusion and flow initiation procedures. Laser speckle imaging permitted robust (pseudo-) quantitative assessment of relative microcirculatory flow and standard bypass grafting resulted in significantly higher postoperative baseline perfusion values in ACVD and MMD. The applicability and sensitivity of LSI was shown by a significantly reduced CO2 reactivity in ACVD (9.6±9%) and MMD (8.5±8%) compared with control (31.2±5%; P<0.0001). In high- and intermediate-flow bypass patients, LSI was characterized by a dynamic real-time response to acute perfusion changes and ultimately confirmed a sufficient flow substitution through the bypass graft. Thus, LSI can be used for sensitive and continuous, non-invasive real-time visualization and measurement of relative cortical CBF in excellent spatial-temporal resolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.