Evidence map›Paper›PMID 23511908›Full record

ReviewNature reviews. Neuroscience2013

Corticostriatal connectivity and its role in disease.

Gordon M G Shepherd

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 467 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
467citing papers in PubMed, 1 pooled it
32.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

467 citing papers in PubMed, 1 synthesis or guideline pooled it, 869 citations in OpenAlex.

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407 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gordon M G ShepherdDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. g-shepherd@ northwestern.edu
Northwestern University · US

Funding

Synaptic Circuit Organization of Motor CortexR01NS061963 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHEPHERD, GORDON M · 2008 to 2022
$5.4M
Synaptic circuit organization of motor cortexR37NS061963 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gordon M Shepherd · 2024 to 2026
$1.6M
NINDS NIH HHS NS061963NINDS NIH HHS R01 NS061963NINDS NIH HHS R37 NS061963
6 · The paper itself

Abstract

Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders - autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.

Indexed as

AnimalsCerebral CortexCorpus StriatumDevelopmental DisabilitiesHumansMental DisordersMovement DisordersNeural PathwaysNeurons

Identifiers

PMID23511908
PMCPMC4096337
OpenAlexW2032996762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.