Trial reportAnnals of surgery2014
Occurrence of multiorgan dysfunction in pediatric burn patients: incidence and clinical outcome.
Trial report in Annals of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Effects of different duration exercise programs in children with severe burns.Burns : journal of the International Society for Burn Injuries · 2017Trial
- Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study.Shock (Augusta, Ga.) · 2015Trial
- Multi-Organ Failure in Adult Patients Admitted to Intensive Care with Severe Burns-A Retrospective Cohort Study.European burn journal · 2026Article
- A Characterization of Pediatric Burn Injury Patients Presenting to a Zonal Referral Hospital in Northern Tanzania.Journal of burn care & research : official publication of the American Burn Association · 2026Observational
- Recent Advances in Antimicrobial Proteins and Peptides: A Promising Clinical Breakthrough and Patent Landscape.Current protein & peptide science · 2026Review
- Gastrointestinal insufficiency is a risk factor for severely burned patients: a case-control study among 185 victims in Kunshan explosion.BMC gastroenterology · 2025Article
- Health Care Resource Use and Costs After Hospitalization With Multiple Organ Dysfunction in Children.JAMA network open · 2025Article
- Ten-Year Retrospective Analysis of Continuous Renal Replacement Therapy in Burn Patients: Impact on Survival and Timing of Initiation.Annals of transplantation · 2024Article
- Lung Protection After Severe Thermal Burns With Adenosine, Lidocaine, and Magnesium (ALM) Resuscitation and Importance of Shams in a Rat Model.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- Cardiometabolic disease risk markers are increased following burn injury in children.Frontiers in public health · 2023Article
- Long-Term Effects of Severe Burns on the Kidneys: Research Advances and Potential Therapeutic Approaches.Journal of inflammation research · 2023Review
- Systemic anti-inflammatory effects of mesenchymal stem cells in burn: A systematic review of animal studies.Journal of clinical and translational research · 2022Review
- Article
- Article
- The role of matrix metalloproteinase-9 and its inhibitor TIMP-1 in burn injury: a systematic review.International journal of burns and trauma · 2021Review
- Early Prediction of Multiple Organ Dysfunction in the Pediatric Intensive Care Unit.Frontiers in pediatrics · 2021Article
- Protective Effects of Melatonin against Severe Burn-Induced Distant Organ Injury: A Systematic Review and Meta-Analysis of Experimental Studies.Antioxidants (Basel, Switzerland) · 2020Review
- Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma.Burns open : an international open access journal for burn injuries · 2020Article
- Reversible dilative cardiomyopathy after electrical injury: a case report.Journal of medical case reports · 2018Article
- Pathophysiological Response to Burn Injury in Adults.Annals of surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the incidence of single or multiple organ failure postburn and its resultant clinical outcomes during acute hospitalization.
backgroundPatient outcomes are inherently dependent on intact organ function; however, burn injury affects the structure and function of almost every organ, but especially lung, liver, kidney, and heart. Therefore, single-organ failure and/or multiorgan failure (MOF) are thought to contribute significantly to postburn morbidity and mortality, but to date no large trial examining the effects of MOF on postburn outcomes exists.
methodsIncidence of MOF was monitored in 821 pediatric burn patients during acute hospitalization. Patients were divided into groups on the basis of the incidence of single-organ-specific failure, MOF, and non-MOF. The DENVER2 score was used to assess organ-specific scores for lung, liver, kidney, and heart. The patient's demographics, injury characteristics, and outcome parameters were recorded.
resultsRespiratory failure has the highest incidence in the early phase of postburn injury and decreases starting 5 days postburn. Cardiac failure was noted to have the highest incidence throughout hospital stay. Incidence of hepatic failure increases with the hospital length of stay and is associated with a high mortality during the late phase of the acute hospital stay. Renal failure has an unexpectedly low incidence but is associated with a high mortality during the first 3 weeks postburn injury. Three or more organ failure is associated with very high mortality.
conclusionsThis is the first large study in burn patients to determine the incidence of organ-specific failure and outcome. The results of this study confirmed the expected chronologic incidence of organ-specific failure and yield the long-term mortality from liver and renal failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.