ArticleThe American journal of psychiatry2013
Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.
Article in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- Effects of acute memantine administration on MATRICS Consensus Cognitive Battery performance in psychosis: Testing an experimental medicine strategy.Psychopharmacology · 2016Trial
- The role of plasma oxytocin in early-onset schizophrenia: implications for disease severity and early intervention.BMC psychiatry · 2026Article
- Whole-Exome and Whole-Genome Sequencing of Candidate Pharmacogenomic and Schizophrenia-Related Genes in Sudanese Families with Schizophrenia.Pharmacogenomics and personalized medicine · 2026Article
- Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders.Molecular psychiatry · 2024Article
- Genetic Influences on Cognitive Dysfunction in Schizophrenia.Current topics in behavioral neurosciences · 2023Article
- Auditory affective processing, musicality, and the development of misophonic reactions.Frontiers in neuroscience · 2022Review
- Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.International journal of molecular sciences · 2021Review
- Heritability of acoustic startle magnitude and latency from the consortium on the genetics of schizophrenia.Schizophrenia research · 2020Article
- Genetics of schizophrenia (Review).Experimental and therapeutic medicine · 2020Review
- P50 inhibitory sensory gating in schizophrenia: analysis of recent studies.Schizophrenia research · 2020Article
- Common Data Elements for National Institute of Mental Health-Funded Translational Early Psychosis Research.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
- Adolescent stress contributes to aberrant dopamine signaling in a heritable rodent model of susceptibility.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study.JAMA psychiatry · 2019Article
- Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms.Journal of psychiatry and brain science · 2019Article
- Sensorimotor gating deficits in "two-hit" models of schizophrenia risk factors.Schizophrenia research · 2018Review
- Recent Advances in the Genetics of Schizophrenia.Molecular neuropsychiatry · 2018Review
- Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.Schizophrenia research. Cognition · 2018Article
- Thalamic Reticular Dysfunction as a Circuit Endophenotype in Neurodevelopmental Disorders.Neuron · 2018Review
- What's the story? A computational analysis of narrative competence in autism.Autism : the international journal of research and practice · 2018Article
12 more citing papers are in PubMed but not listed here.
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25 authors.
Funding
Abstract
objectiveThe Consortium on the Genetics of Schizophrenia has undertaken a large multisite study to characterize 12 neurophysiological and neurocognitive endophenotypic measures as a step toward understanding the complex genetic basis of schizophrenia. The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated.
methodEach family consisted of a proband with schizophrenia, at least one unaffected sibling, and both parents. A total of 1,286 participants from 296 families were genotyped in two phases, and 1,004 individuals were also assessed for the endophenotypes. Linkage analyses of the 6,055 single-nucleotide polymorphisms that were successfully assayed, 5,760 of which were common to both phases, were conducted using both variance components and pedigree-wide regression methods.
resultsLinkage analyses of the 12 endophenotypes collectively identified one region meeting genome-wide significance criteria, with a LOD (log of odds) score of 4.0 on chromosome 3p14 for the antisaccade task, and another region on 1p36 nearly meeting genome-wide significance, with a LOD score of 3.5 for emotion recognition. Chromosomal regions meeting genome-wide suggestive criteria with LOD scores >2.2 were identified for spatial processing (2p25 and 16q23), sensorimotor dexterity (2q24 and 2q32), prepulse inhibition (5p15), the California Verbal Learning Test (8q24), the degraded-stimulus Continuous Performance Test (10q26), face memory (10q26 and 12p12), and the Letter-Number Span (14q23).
conclusionsTwelve regions meeting genome-wide significant and suggestive criteria for previously identified heritable, schizophrenia-related endophenotypes were observed, and several genes of potential neurobiological interest were identified. Replication and further genomic studies are needed to assess the biological significance of these results.
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