Evidence map›Paper›PMID 23511582›Full record

ReviewGut microbes

Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer.

Maya Raman, Padma Ambalam, Kanthi Kiran Kondepudi, Sheetal Pithva, Charmy Kothari, Arti T Patel, Ravi Kiran Purama, J M Dave, B R M Vyas

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 262 citations in OpenAlex.

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  20. Potential of Synbiotics and Probiotics as Chemopreventive Agent.Probiotics and antimicrobial proteins · 2024
    Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Maya RamanDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences and Bioengineering, Indian Institute of Technology, Chennai, India.
Padma Ambalam
Kanthi Kiran Kondepudi
Sheetal Pithva
Charmy Kothari
Arti T Patel
Ravi Kiran Purama
J M Dave
B R M Vyas
Concordia University Irvine · USSaurashtra University · INAnand Agricultural University · INLund University · SENational Agri-Food Biotechnology Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal Cancer (CRC) is the second leading cause of cancer-related mortality and is the fourth most common malignant neoplasm in USA. Escaping apoptosis and cell mutation are the prime hallmarks of cancer. It is apparent that balancing the network between DNA damage and DNA repair is critical in preventing carcinogenesis. One-third of cancers might be prevented by nutritious healthy diet, maintaining healthy weight and physical activity. In this review, an attempt is made to abridge the role of carcinogen in colorectal cancer establishment and prognosis, where special attention has been paid to food-borne mutagens and functional role of beneficial human gut microbiome in evading cancer. Further the significance of tailor-made prebiotics, probiotics and synbiotics in cancer management by bio-antimutagenic and desmutagenic activity has been elaborated. Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host. Prebiotics are a selectively fermentable non-digestible oligosaccharide or ingredient that brings specific changes, both in the composition and/or activity of the gastrointestinal microflora, conferring health benefits. Synbiotics are a combination of probiotic bacteria and the growth promoting prebiotic ingredients that purport "synergism."

Indexed as

PrebioticsSynbioticsAntimutagenic AgentsColorectal NeoplasmsGastrointestinal TractHumansImmunologic FactorsMetagenomeProbioticsUnited StatesAntimutagenic AgentsImmunologic FactorsPrebioticsantimutagenscancercolorectal cancerhetercyclic aminesmutagenspolyaromatic hydrocarbonsprebioticsprobioticssynbiotics

Identifiers

PMID23511582
PMCPMC3669163
OpenAlexW2015257909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.