ArticleThe American journal of psychiatry2013
Does fetal exposure to SSRIs or maternal depression impact infant growth?
Article in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy.The American journal of psychiatry · 2018Pooled it
- Prenatal depression and adverse birth outcomes: an updated systematic review.Maternal and child health journal · 2015Pooled it
- A randomized controlled trial of an electronic patient decision aid (PDA) for decision-making around antidepressant use in pregnancy.Archives of women's mental health · 2026Trial
- The association between perinatal depressive symptoms and child neurodevelopment.American journal of obstetrics & gynecology MFM · 2024Trial
- A patient decision aid for antidepressant use in pregnancy: study protocol for a randomized controlled trial.Trials · 2016Trial
- Depression and antidepressant treatment in growing up in New Zealand: impact on preterm birth and low birth weight.Archives of women's mental health · 2026Article
- Early pregnancy depressive symptoms and severe maternal morbidity.American journal of obstetrics & gynecology MFM · 2026Article
- Predicting newborn birth outcomes with prenatal maternal health features and correlates in the United States: a machine learning approach using archival data.BMC pregnancy and childbirth · 2024Article
- Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring.Journal of clinical medicine · 2024Review
- Depression Treatment in Pregnancy: Is It Safe, or Is It Not?International journal of environmental research and public health · 2024Review
- Overweight and glucose/lipid metabolism abnormality associated with SSRIs: a pharmacovigilance study based on the FDA adverse event reporting system.Frontiers in pharmacology · 2024Article
- Article
- Psychiatric disorders during pregnancy in asymptomatic and mildly symptomatic SARS-CoV-2 positive women: Prevalence and effect on outcome.Psychiatry research · 2023Article
- A qualitative examination of the implementation of a perinatal collaborative care program.Primary health care research & development · 2022Article
- Growth failure in infants with neonatal abstinence syndrome in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Trajectories of antenatal depression and adverse pregnancy outcomes.American journal of obstetrics and gynecology · 2022Article
- Increased Depression Screening and Treatment Recommendations After Implementation of a Perinatal Collaborative Care Program.Psychiatric services (Washington, D.C.) · 2021Article
- Maternal depressive symptoms and stress during pregnancy as predictors of gestational age at birth and standardized body mass index from birth up to 2 years of age.BMC pregnancy and childbirth · 2021Article
- Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Meta-Analysis of Pharmacotherapy.Psychiatric research and clinical practice · 2021Review
- Prenatal Maternal Objective and Subjective Stress Exposures and Rapid Infant Weight Gain.The Journal of pediatrics · 2020Observational
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of this study was to compare the growth of infants born to women with antenatal major depressive disorder, either untreated or treated with selective serotonin reuptake inhibitor (SSRI) antidepressants, and infants born to a nondepressed, nonmedicated comparison group across the first year of life.
methodIn this prospective observational study, pregnant women were evaluated at weeks 20, 30, and 36 of gestation, and mother and infant pairs were assessed at 2, 12, 26, and 52 weeks postpartum. Three nonoverlapping groups of women were defined according to their pregnancy exposures: 1) no SSRI and no depression (N=97), 2) SSRI (N=46), and 3) major depression without SSRI (N=31). Maternal demographic and clinical characteristics and newborn outcomes were compared across exposure groups. Infant weight, length, and head circumference were measured by a physician or physician's assistant who was blind to depression and SSRI exposure status at each postpartum time point.
resultsBoth adjusted and unadjusted analyses revealed neither antenatal major depression nor SSRI exposure was significantly associated with infant weight, length, or head circumference relative to nonexposure to either. In addition, the interaction of group and prepregnancy body mass index was also evaluated, and no significant synergistic effect was identified. Similarly, no differential effect of group over time was observed for weight, length, or head circumference.
conclusionsIn utero exposure to major depression or SSRI antidepressants did not affect infant growth with respect to weight, length, or head circumference from birth through 12 months of age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.