ArticleChannels (Austin, Tex.)
The topology of the C-terminal sections of the NCX1 Na (+) /Ca ( 2+) exchanger and the NCKX2 Na (+) /Ca ( 2+) -K (+) exchanger.
Article in Channels (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Structural and functional mapping of ion access pathways in the human KChannels (Austin, Tex.) · 2025Article
- The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025Review
- Modulation of the cardiac NaCell calcium · 2020Review
- Cardiac NaThe journal of physiological sciences : JPS · 2019Review
- The prokaryotic NaThe Journal of general physiology · 2018Article
- Two Variants inG3 (Bethesda, Md.) · 2017Article
- Phylogenetic analysis and protein structure modelling identifies distinct Ca(2+)/Cation antiporters and conservation of gene family structure within Arabidopsis and rice species.Rice (New York, N.Y.) · 2016Article
- Inhibitory effect of YM-244769, a novel NaNaunyn-Schmiedeberg's archives of pharmacology · 2016Article
- A Functional Study of Mutations in K+-dependent Na+-Ca2+ Exchangers Associated with Amelogenesis Imperfecta and Non-syndromic Oculocutaneous Albinism.The Journal of biological chemistry · 2016Article
- Nicorandil stimulates a Na⁺/Ca²⁺ exchanger by activating guanylate cyclase in guinea pig cardiac myocytes.Pflugers Archiv : European journal of physiology · 2016Article
- Article
- Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle.The Journal of biological chemistry · 2014Article
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
Abstract
Mammalian Na (+) /Ca ( 2+) (NCX) and Na (+) /Ca ( 2+) -K (+) exchangers (NCKX) are polytopic membrane proteins that play critical roles in calcium homeostasis in many cells. Although hydropathy plots for NCX and NCKX are very similar, reported topological models for NCX1 and NCKX2 differ in the orientation of the three C-terminal transmembrane segments (TMS). NCX1 is thought to have 9 TMS and a re-entrant loop, whereas NCKX2 is thought to have 10 TMS. The current topological model of NCKX2 is very similar to the 10 membrane spanning helices seen in the recently reported crystal structure of NCX_MJ, a distantly related archaebacterial Na (+) /Ca ( 2+) exchanger. Here we reinvestigate the orientation of the three C-terminal TMS of NCX1 and NCKX2 using mass-tagging experiments of substituted cysteine residues. Our results suggest that NCX1, NCKX2 and NCX_MJ all share the same 10 TMS topology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.