ArticleDiagnostic pathology2013
Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature.
Article in Diagnostic pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Transcriptomic changes in eutopic endometrium and ectopic lesions during endometriosis progression in a mouse model.F&S science · 2024Article
- A case of acute liver failure due to aggressive natural killer-cell leukemia with a rapid course.Clinical journal of gastroenterology · 2023Review
- Primary pulmonary extranodal NK/T-cell lymphoma of nasal type misdiagnosed as pneumonia: A case report and literature review.Medicine · 2017Review
- Aggressive natural killer cell leukemia or extranodal NK/T cell lymphoma? a case with nasal involvement.Diagnostic pathology · 2017Article
- Article
- Spontaneous Hepatic Rupture Associated With Epstein-Barr Virus Negative Aggressive Natural Killer Cell Leukemia.World journal of oncology · 2014Article
- Primary spleen extranodal NK/T cell lymphoma, nasal type, with bone marrow involvement and CD30 positive expression: a case report and literature review.Diagnostic pathology · 2014Review
- Coexistent hairy cell leukaemia and hepatosplenic T-cell lymphoma: a case report.Diagnostic pathology · 2014Article
- Identification of genuine primary pulmonary NK cell lymphoma via clinicopathologic observation and clonality assay.Diagnostic pathology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare aggressive form of NK-cell neoplasm. We report an uncommon case of 36-year-old male who showed jaundice and spontaneous splenic rupture. The diagnosis was established by the biopsy of liver and spleen. The monomorphous medium-size neoplastic cells infiltrated into portal areas and sinus of liver as well as the cords and sinus of the spleen. Necrosis, mitotic figures and significant apoptosis could be seen easily. These neoplastic cells demonstrated a typical immunophenotype of CD3ε+, CD56+, CD16+, Granzyme B+, TIA-1+. T-cell receptor γ (TCR-γ) gene rearrangement analysis showed germline configuration and the result of in situ hybridization for Epstein-Barr virus-encoded RNA (EBER-ISH) was positive. The patient has undergone an aggressive clinical course and died of multi-organ function failure 14 days later after admission. To the best of our knowledge, this is the first case of ANKL with spontaneous splenic rupture, and we should pay more attention to recognize it. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2048154883890867.
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