Trial reportBMC geriatrics2013
The minimal clinically important difference of six-minute walk in Asian older adults.
Trial report in BMC geriatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Objectively measured physical activity following lumbar decompression surgery: systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Determining the minimum important differences for field walking tests in adults with long-term conditions: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Short-Term (<8 wk) High-Intensity Interval Training in Diseased Cohorts.Medicine and science in sports and exercise · 2018Pooled it
- Minimal clinically important difference for the 6-min walk test: literature review and application to Morquio A syndrome.Orphanet journal of rare diseases · 2017Pooled it
- Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty.Cell stem cell · 2026Trial
- Feasibility of unsupervised, home-based leg heat therapy in older adults: a pilot, sham-controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- A two-arm non-randomised trial of MedEx IMPACT: a community-based, physical activity behaviour change intervention for survivors of cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Effect of manual diaphragmatic release on ventilatory function and functional capacity in elderly type 2 diabetic women: A randomised controlled trial.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2026Article
- Changes in physical performance and frailty-associated risk associated with participation in a community exercise programme: Findings from the ExWell cohort.The Journal of frailty & aging · 2026Article
- Home-Based Virtual Reality Exercise and Resistance Training for Enhanced Cardiorespiratory Fitness in Community-Dwelling Older People with Sarcopenia: A Randomized, Double-Blind Controlled Trial.Life (Basel, Switzerland) · 2025Article
- Article
- Assessing a GPS-Based 6-Minute Walk Test for People With Persistent Pain: Validation Study.JMIR formative research · 2024Article
- Analysis of factors associated with 6MWD among older patients with chronic heart failure.The Journal of international medical research · 2023Observational
- Effects of Physiatrist and Physiotherapist-supervised Therapeutic Exercise on Physical Function in Frail Older Patients with Multimorbidity.Progress in rehabilitation medicine · 2023Article
- Health and wellness for disadvantaged older adults: The AFRESH pilot study.PEC innovation · 2022Article
- Article
- Challenges in the Development of Drugs for Sarcopenia and Frailty - Report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force.The Journal of frailty & aging · 2022Article
- Peer-led exercise program for ageing adults to improve physical functions - a randomized trial.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2021Article
- Falling risk in patients with end-stage knee osteoarthritis.Clinical rheumatology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRehabilitation interventions promote functional recovery among frail older adults and little is known about the clinical significance of physical outcome measure changes. The purpose of our study is to examine the minimal clinically important difference (MCID) for the 6-minute walk distance (6MWD) among frail Asian older adults.
methodsData from the "Evaluation of the Frails' Fall Efficacy by Comparing Treatments" study were analyzed. Distribution-based and anchor-based methods were used to estimate the MCID of the 6MWD. Participants who completed the trial rated their perceived change of overall health on the Global Rating of Change (GROC) scale. The receiver operating characteristic curve (ROC) was used to analyze the sensitivity and specificity of the cut-off values of 6MWD (in meters) for GROC rating of "a little bit better" (+2), based on feedback from participants.
resultsThe mean (SD) change in 6MWD was 37.3(46.2) m among those who perceived a change (GROC ≥ 2), while those who did not was 9.3(18.2) m post-intervention (P = 0.011). From the anchor-based method, the MCID value for the 6MWD was 17.8 m (sensitivity 56.7% and specificity 83.3%) while distribution-based method estimated 12.9 m.
conclusionThe MCID estimate for 6MWD was 17.8 m in the moderately frail Asian older adults with a fear of falling. The results will aid the clinicians in goal setting for this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.