ArticleThe Journal of organic chemistry2013
Skeletal diversification via heteroatom linkage control: preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols.
Article in The Journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Synthesis of 3,3-oxaspirocycles via cobalt-catalyzed cascade C-H activation and carboamidation of alkynes.Communications chemistry · 2025Article
- C-H Insertion via Ruthenium CatalyzedJournal of the American Chemical Society · 2022Article
- Oxa-spirocycles: synthesis, properties and applications.Chemical science · 2021Article
- Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones.Angewandte Chemie (International ed. in English) · 2021Article
- Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.Organic & biomolecular chemistry · 2016Article
- Synthesis of a family of spirocyclic scaffolds: building blocks for the exploration of chemical space.The Journal of organic chemistry · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The discovery and application of a new branching pathway synthesis strategy that rapidly produces skeletally diverse scaffolds is described. Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the other, a spirocyclic 3-furanone, are each obtained using a two-step sequence featuring a common first step. Both scaffold types lead to intermediates that can be orthogonally diversified using the same final components. One of the scaffold types was obtained in sufficiently high yield that it was immediately used to produce a 97-compound library.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.